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Helicobacter pylori infection is the major risk factor for atrophic gastritis.
Am J Gastroenterol. 1996 May; 91(5):959-62.AJ

Abstract

OBJECTIVE

To evaluate the association of both Helicobacter pylori (Hp) infection and advancing age with increased prevalence of atrophic gastritis.

METHODS

Two hundred and thirty-eight subjects who had no esophagitis, peptic ulcers, or malignancies in the upper gastrointestinal tract were divided into three groups according to age: group A, < 30 yr; group B, 30-49 yr; group C, > or = 50 yr. Two biopsy specimens were obtained from the lesser curvature of the antrum and two from the anterior and posterior walls of the fundus to assess the degree of gastritis and histological evidence of Hp infection. Hp infection was evaluated by Giemsa staining and serum IgG antibodies. Serum gastrin (SG) and pepsinogen (PG) were determined by radioimmunoassay.

RESULTS

In all age groups, the prevalence of atrophic gastritis was significantly more common in subjects with evidence of Hp infection. In Hp-positive subjects, the prevalence of atrophic gastritis increased with advancing age. Atrophic gastritis was extremely rare, regardless of age, in Hp-uninfected patients. SG increased, and PG I and the PG I:II ratio decreased with age in Hp-positive subjects. This trend was not apparent in Hp-negative subjects.

CONCLUSION

Our results suggest that Hp infection is a stronger predictor than advancing age for atrophic gastritis.

Authors+Show Affiliations

First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8633588

Citation

Kawaguchi, H, et al. "Helicobacter Pylori Infection Is the Major Risk Factor for Atrophic Gastritis." The American Journal of Gastroenterology, vol. 91, no. 5, 1996, pp. 959-62.
Kawaguchi H, Haruma K, Komoto K, et al. Helicobacter pylori infection is the major risk factor for atrophic gastritis. Am J Gastroenterol. 1996;91(5):959-62.
Kawaguchi, H., Haruma, K., Komoto, K., Yoshihara, M., Sumii, K., & Kajiyama, G. (1996). Helicobacter pylori infection is the major risk factor for atrophic gastritis. The American Journal of Gastroenterology, 91(5), 959-62.
Kawaguchi H, et al. Helicobacter Pylori Infection Is the Major Risk Factor for Atrophic Gastritis. Am J Gastroenterol. 1996;91(5):959-62. PubMed PMID: 8633588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection is the major risk factor for atrophic gastritis. AU - Kawaguchi,H, AU - Haruma,K, AU - Komoto,K, AU - Yoshihara,M, AU - Sumii,K, AU - Kajiyama,G, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 959 EP - 62 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 91 IS - 5 N2 - OBJECTIVE: To evaluate the association of both Helicobacter pylori (Hp) infection and advancing age with increased prevalence of atrophic gastritis. METHODS: Two hundred and thirty-eight subjects who had no esophagitis, peptic ulcers, or malignancies in the upper gastrointestinal tract were divided into three groups according to age: group A, < 30 yr; group B, 30-49 yr; group C, > or = 50 yr. Two biopsy specimens were obtained from the lesser curvature of the antrum and two from the anterior and posterior walls of the fundus to assess the degree of gastritis and histological evidence of Hp infection. Hp infection was evaluated by Giemsa staining and serum IgG antibodies. Serum gastrin (SG) and pepsinogen (PG) were determined by radioimmunoassay. RESULTS: In all age groups, the prevalence of atrophic gastritis was significantly more common in subjects with evidence of Hp infection. In Hp-positive subjects, the prevalence of atrophic gastritis increased with advancing age. Atrophic gastritis was extremely rare, regardless of age, in Hp-uninfected patients. SG increased, and PG I and the PG I:II ratio decreased with age in Hp-positive subjects. This trend was not apparent in Hp-negative subjects. CONCLUSION: Our results suggest that Hp infection is a stronger predictor than advancing age for atrophic gastritis. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/8633588/Helicobacter_pylori_infection_is_the_major_risk_factor_for_atrophic_gastritis_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -