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Antimüllerian hormone as a serum marker of granulosa cell tumorsof the ovary: comparative study with serum alpha-inhibin and estradiol.

Abstract

OBJECTIVE

Our purpose was to evaluate serum antimüllerian hormone as a marker for granulosa cell tumors.

STUDY DESIGN

Serum antimüllerian hormone concentrations were determined in 16 patients with an adult-type granulosa cell tumor; in female patients with ovarian adenocarcinoma, benign ovarian cysts, or extraovarian cancers; and in normal premenopausal and postmenopausal women. Serum antimüllerian hormone, alpha-inhibin, and estradiol levels were compared in 10 patients with a granulosa cell tumor during 6 to 47 months of follow-up.

RESULTS

Serum antimüllerian hormone was undetectable in normal postmenopausal women and was <5 micrograms/L in premenopausal women. Normal serum levels were found in patients with ovarian cancers or cysts or with extraovarian cancers. Levels were between 6.8 and 117.9 microg/L in eight of nine patients with a progressive granulosa cell tumor. In the remaining case antimüllerian hormone, alpha-inhibin and estradiol concentrations were normal. Serum antimüllerian hormone and alpha-inhibin levels became elevated at least 11 months before the recurrence was clinically detectable. During clinical remission serum antimullerian hormone, beta-inhibin, and estradiol were normal in most cases.

CONCLUSION

Serum antimüllerian hormone is a sensitive, specific, reliable marker of adult-type granulosa cell tumors and is useful to evaluate the efficacy of treatment and to detect recurrences early.

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  • Authors+Show Affiliations

    ,

    Institut National de la Santé et de la Recherche Médicale, Montrouge, France.

    , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Anti-Mullerian Hormone
    Biomarkers, Tumor
    Estradiol
    Female
    Follow-Up Studies
    Glycoproteins
    Granulosa Cell Tumor
    Growth Inhibitors
    Humans
    Inhibins
    Middle Aged
    Ovarian Neoplasms
    Peptides
    Predictive Value of Tests
    Sensitivity and Specificity
    Testicular Hormones

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8633676

    Citation

    Rey, R A., et al. "Antimüllerian Hormone as a Serum Marker of Granulosa Cell Tumorsof the Ovary: Comparative Study With Serum Alpha-inhibin and Estradiol." American Journal of Obstetrics and Gynecology, vol. 174, no. 3, 1996, pp. 958-65.
    Rey RA, Lhommé C, Marcillac I, et al. Antimüllerian hormone as a serum marker of granulosa cell tumorsof the ovary: comparative study with serum alpha-inhibin and estradiol. Am J Obstet Gynecol. 1996;174(3):958-65.
    Rey, R. A., Lhommé, C., Marcillac, I., Lahlou, N., Duvillard, P., Josso, N., & Bidart, J. M. (1996). Antimüllerian hormone as a serum marker of granulosa cell tumorsof the ovary: comparative study with serum alpha-inhibin and estradiol. American Journal of Obstetrics and Gynecology, 174(3), pp. 958-65.
    Rey RA, et al. Antimüllerian Hormone as a Serum Marker of Granulosa Cell Tumorsof the Ovary: Comparative Study With Serum Alpha-inhibin and Estradiol. Am J Obstet Gynecol. 1996;174(3):958-65. PubMed PMID: 8633676.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antimüllerian hormone as a serum marker of granulosa cell tumorsof the ovary: comparative study with serum alpha-inhibin and estradiol. AU - Rey,R A, AU - Lhommé,C, AU - Marcillac,I, AU - Lahlou,N, AU - Duvillard,P, AU - Josso,N, AU - Bidart,J M, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 958 EP - 65 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 174 IS - 3 N2 - OBJECTIVE: Our purpose was to evaluate serum antimüllerian hormone as a marker for granulosa cell tumors. STUDY DESIGN: Serum antimüllerian hormone concentrations were determined in 16 patients with an adult-type granulosa cell tumor; in female patients with ovarian adenocarcinoma, benign ovarian cysts, or extraovarian cancers; and in normal premenopausal and postmenopausal women. Serum antimüllerian hormone, alpha-inhibin, and estradiol levels were compared in 10 patients with a granulosa cell tumor during 6 to 47 months of follow-up. RESULTS: Serum antimüllerian hormone was undetectable in normal postmenopausal women and was <5 micrograms/L in premenopausal women. Normal serum levels were found in patients with ovarian cancers or cysts or with extraovarian cancers. Levels were between 6.8 and 117.9 microg/L in eight of nine patients with a progressive granulosa cell tumor. In the remaining case antimüllerian hormone, alpha-inhibin and estradiol concentrations were normal. Serum antimüllerian hormone and alpha-inhibin levels became elevated at least 11 months before the recurrence was clinically detectable. During clinical remission serum antimullerian hormone, beta-inhibin, and estradiol were normal in most cases. CONCLUSION: Serum antimüllerian hormone is a sensitive, specific, reliable marker of adult-type granulosa cell tumors and is useful to evaluate the efficacy of treatment and to detect recurrences early. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/8633676/Antimüllerian_hormone_as_a_serum_marker_of_granulosa_cell_tumorsof_the_ovary:_comparative_study_with_serum_alpha_inhibin_and_estradiol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(96)70333-2 DB - PRIME DP - Unbound Medicine ER -