Tags

Type your tag names separated by a space and hit enter

Intramuscular prochlorperazine versus metoclopramide as single-agent therapy for the treatment of acute migraine headache.
Am J Emerg Med. 1996 May; 14(3):262-4.AJ

Abstract

To compare the efficacy of intramuscular prochlorperazine and metoclopramide in the short-term treatment of migraine headache in the emergency department 86 eligible adult patients with moderate to severe migraine headache were evaluated prospectively at a university-affiliated community hospital. After randomization, each subject received a 2-mL intramuscular injection of sterile saline, prochlorperazine (10 mg), or metoclopramide (10 mg). No other analgesics were administered during the 60-minute study period; patient assessment of relief was followed using visual analog scales. Reduction in median headache scores was significantly better among those treated with prochlorperazine (67%) compared to metoclopramide (34%) or placebo (16%). Similarly, symptoms of nausea and vomiting were significantly relieved in the prochlorperazine group (chi 2 = 17.1, P < .001). However, rescue analgesic therapy was necessary in the majority of patients treated with prochlorperazine (16/28) and metoclopramide (23/29) after the 60-minute study period. Although intramuscular prochlorperazine appears to provides more effective relief than metoclopramide, these results do not recommend either drug as single-agent therapy for acute migraine headache.

Authors+Show Affiliations

Department of Emergency Medicine, Butterworth Hospital, Michigan State University College of Human Medicine, Grand Rapids 49503, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8639197

Citation

Jones, J, et al. "Intramuscular Prochlorperazine Versus Metoclopramide as Single-agent Therapy for the Treatment of Acute Migraine Headache." The American Journal of Emergency Medicine, vol. 14, no. 3, 1996, pp. 262-4.
Jones J, Pack S, Chun E. Intramuscular prochlorperazine versus metoclopramide as single-agent therapy for the treatment of acute migraine headache. Am J Emerg Med. 1996;14(3):262-4.
Jones, J., Pack, S., & Chun, E. (1996). Intramuscular prochlorperazine versus metoclopramide as single-agent therapy for the treatment of acute migraine headache. The American Journal of Emergency Medicine, 14(3), 262-4.
Jones J, Pack S, Chun E. Intramuscular Prochlorperazine Versus Metoclopramide as Single-agent Therapy for the Treatment of Acute Migraine Headache. Am J Emerg Med. 1996;14(3):262-4. PubMed PMID: 8639197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intramuscular prochlorperazine versus metoclopramide as single-agent therapy for the treatment of acute migraine headache. AU - Jones,J, AU - Pack,S, AU - Chun,E, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 262 EP - 4 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 14 IS - 3 N2 - To compare the efficacy of intramuscular prochlorperazine and metoclopramide in the short-term treatment of migraine headache in the emergency department 86 eligible adult patients with moderate to severe migraine headache were evaluated prospectively at a university-affiliated community hospital. After randomization, each subject received a 2-mL intramuscular injection of sterile saline, prochlorperazine (10 mg), or metoclopramide (10 mg). No other analgesics were administered during the 60-minute study period; patient assessment of relief was followed using visual analog scales. Reduction in median headache scores was significantly better among those treated with prochlorperazine (67%) compared to metoclopramide (34%) or placebo (16%). Similarly, symptoms of nausea and vomiting were significantly relieved in the prochlorperazine group (chi 2 = 17.1, P < .001). However, rescue analgesic therapy was necessary in the majority of patients treated with prochlorperazine (16/28) and metoclopramide (23/29) after the 60-minute study period. Although intramuscular prochlorperazine appears to provides more effective relief than metoclopramide, these results do not recommend either drug as single-agent therapy for acute migraine headache. SN - 0735-6757 UR - https://www.unboundmedicine.com/medline/citation/8639197/Intramuscular_prochlorperazine_versus_metoclopramide_as_single_agent_therapy_for_the_treatment_of_acute_migraine_headache_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-6757(96)90171-0 DB - PRIME DP - Unbound Medicine ER -