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Histones and chromatin structure in hyperthermophilic Archaea.
FEMS Microbiol Rev. 1996 May; 18(2-3):203-13.FM

Abstract

HMf is a histone from the hyperthermophile Methanothermus fervidus. It is the archetype and most studied member of a family of archaeal histones that have primary sequences and three-dimensional structures in common with the eukaryal nucleosome core histones and that bind and compact DNA molecules into nucleosome-like structures (NLS). HMf preparations are mixtures of two similar, small (approximately 7.5 kDa) polypeptides designated HMfA and HMfB that in vivo form both homodimers and heterodimers. HMfA synthesis predominates during exponential growth but the relative amount of HMfB increases as M. fervidus cells enter the stationary growth phase. Analyses of homogeneous preparations of recombinant (r) (HMfA)2 and (rHMfB)2 have demonstrated that these proteins have different DNA-binding and compaction properties in vitro, consistent with different roles in vivo for the (HMfA)2, (HMfB)2 and HMfA. HmfB dimers, and for the NLS that they form, in regulating gene expression and in genome compaction and stability.

Authors+Show Affiliations

Department of Microbiology, Ohio State University, Columbus 43210, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8639328

Citation

Grayling, R A., et al. "Histones and Chromatin Structure in Hyperthermophilic Archaea." FEMS Microbiology Reviews, vol. 18, no. 2-3, 1996, pp. 203-13.
Grayling RA, Sandman K, Reeve JN. Histones and chromatin structure in hyperthermophilic Archaea. FEMS Microbiol Rev. 1996;18(2-3):203-13.
Grayling, R. A., Sandman, K., & Reeve, J. N. (1996). Histones and chromatin structure in hyperthermophilic Archaea. FEMS Microbiology Reviews, 18(2-3), 203-13.
Grayling RA, Sandman K, Reeve JN. Histones and Chromatin Structure in Hyperthermophilic Archaea. FEMS Microbiol Rev. 1996;18(2-3):203-13. PubMed PMID: 8639328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histones and chromatin structure in hyperthermophilic Archaea. AU - Grayling,R A, AU - Sandman,K, AU - Reeve,J N, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 203 EP - 13 JF - FEMS microbiology reviews JO - FEMS Microbiol Rev VL - 18 IS - 2-3 N2 - HMf is a histone from the hyperthermophile Methanothermus fervidus. It is the archetype and most studied member of a family of archaeal histones that have primary sequences and three-dimensional structures in common with the eukaryal nucleosome core histones and that bind and compact DNA molecules into nucleosome-like structures (NLS). HMf preparations are mixtures of two similar, small (approximately 7.5 kDa) polypeptides designated HMfA and HMfB that in vivo form both homodimers and heterodimers. HMfA synthesis predominates during exponential growth but the relative amount of HMfB increases as M. fervidus cells enter the stationary growth phase. Analyses of homogeneous preparations of recombinant (r) (HMfA)2 and (rHMfB)2 have demonstrated that these proteins have different DNA-binding and compaction properties in vitro, consistent with different roles in vivo for the (HMfA)2, (HMfB)2 and HMfA. HmfB dimers, and for the NLS that they form, in regulating gene expression and in genome compaction and stability. SN - 0168-6445 UR - https://www.unboundmedicine.com/medline/citation/8639328/Histones_and_chromatin_structure_in_hyperthermophilic_Archaea_ L2 - https://academic.oup.com/femsre/article-lookup/doi/10.1111/j.1574-6976.1996.tb00237.x DB - PRIME DP - Unbound Medicine ER -