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Oral contraceptives enhance the risk of clinical manifestation of venous thrombosis at a young age in females homozygous for factor V Leiden.
Br J Haematol. 1996 May; 93(2):487-90.BJ

Abstract

In 29 patients (17 females) homozygous Arg 506 Gln mutation (FV Leiden) was identified. 25 had been investigated because of venous thromboembolism (VTE); four asymptomatic patients were found during family studies. The first VTE had occurred significantly earlier in females (median age [m] 26 years, range 17-49) than in males (m=38 years, range 21-82) (P=0.01). 12 females (80%) had taken oral contraceptives (OC, estrogen content 0.02-0.1 mg) for 6-150 months prior to thrombosis. Further triggering conditions in females were hormone replacement (n=1) and pregnancy (n=2). In 8/10 males the first VTE had occurred spontaneously--in two after surgery. The sites of VTE were deep vein thrombosis, pulmonary embolism, caval vein thrombosis and superficial thrombophlebitis. From our data we conclude that OC medication is the most important precipitating factor for VTE in females with homozygous FV Leiden.

Authors+Show Affiliations

First Department of Medicine, Division of Haematology and Blood Coagulation, University of Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8639453

Citation

Rintelen, C, et al. "Oral Contraceptives Enhance the Risk of Clinical Manifestation of Venous Thrombosis at a Young Age in Females Homozygous for Factor V Leiden." British Journal of Haematology, vol. 93, no. 2, 1996, pp. 487-90.
Rintelen C, Mannhalter C, Ireland H, et al. Oral contraceptives enhance the risk of clinical manifestation of venous thrombosis at a young age in females homozygous for factor V Leiden. Br J Haematol. 1996;93(2):487-90.
Rintelen, C., Mannhalter, C., Ireland, H., Lane, D. A., Knöbl, P., Lechner, K., & Pabinger, I. (1996). Oral contraceptives enhance the risk of clinical manifestation of venous thrombosis at a young age in females homozygous for factor V Leiden. British Journal of Haematology, 93(2), 487-90.
Rintelen C, et al. Oral Contraceptives Enhance the Risk of Clinical Manifestation of Venous Thrombosis at a Young Age in Females Homozygous for Factor V Leiden. Br J Haematol. 1996;93(2):487-90. PubMed PMID: 8639453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptives enhance the risk of clinical manifestation of venous thrombosis at a young age in females homozygous for factor V Leiden. AU - Rintelen,C, AU - Mannhalter,C, AU - Ireland,H, AU - Lane,D A, AU - Knöbl,P, AU - Lechner,K, AU - Pabinger,I, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez KW - Austria KW - Biology KW - Contraception KW - Contraceptive Methods KW - Developed Countries KW - Diseases KW - Embolism KW - Endocrine System KW - Estrogens KW - Europe KW - Examinations And Diagnoses KW - Family Planning KW - Genetics KW - Hormone Replacement Therapy KW - Hormones KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Physiology KW - Research Report KW - Risk Factors KW - Screening KW - Thromboembolism KW - Thrombosis KW - Treatment KW - Vascular Diseases KW - Western Europe SP - 487 EP - 90 JF - British journal of haematology JO - Br J Haematol VL - 93 IS - 2 N2 - In 29 patients (17 females) homozygous Arg 506 Gln mutation (FV Leiden) was identified. 25 had been investigated because of venous thromboembolism (VTE); four asymptomatic patients were found during family studies. The first VTE had occurred significantly earlier in females (median age [m] 26 years, range 17-49) than in males (m=38 years, range 21-82) (P=0.01). 12 females (80%) had taken oral contraceptives (OC, estrogen content 0.02-0.1 mg) for 6-150 months prior to thrombosis. Further triggering conditions in females were hormone replacement (n=1) and pregnancy (n=2). In 8/10 males the first VTE had occurred spontaneously--in two after surgery. The sites of VTE were deep vein thrombosis, pulmonary embolism, caval vein thrombosis and superficial thrombophlebitis. From our data we conclude that OC medication is the most important precipitating factor for VTE in females with homozygous FV Leiden. SN - 0007-1048 UR - https://www.unboundmedicine.com/medline/citation/8639453/Oral_contraceptives_enhance_the_risk_of_clinical_manifestation_of_venous_thrombosis_at_a_young_age_in_females_homozygous_for_factor_V_Leiden_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1048&date=1996&volume=93&issue=2&spage=487 DB - PRIME DP - Unbound Medicine ER -