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Pharmacokinetic profile of topiramate in comparison with other new antiepileptic drugs.
Epilepsia. 1996; 37 Suppl 2:S8-S13.E

Abstract

Antiepileptic drugs (AEDs) in broad use today have a number of pharmacokinetic liabilities, including a propensity for clinically meaningful drug interactions. Therefore, new AEDs with improved pharmacokinetic characteristics would be welcomed. The pharmacokinetic profiles of six newer AEDs--topiramate (TPM), gabapentin (GBP), vigabatrin (VGB), lamotrigine (LTG), oxcarbazepine (OCBZ), and felbamate--were reviewed. Some of these AEDs offer an improvement in one or more pharmacokinetic parameters compared with traditional AEDs, with TPM, GBP, VGB, and OCBZ demonstrating the most advantageous overall pharmacokinetic profiles.

Authors+Show Affiliations

Division of Pharmacology and Toxicology, Department of Medicine and Therapeutics, University of Pavia, Italy.

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

8641245

Citation

Perucca, E. "Pharmacokinetic Profile of Topiramate in Comparison With Other New Antiepileptic Drugs." Epilepsia, vol. 37 Suppl 2, 1996, pp. S8-S13.
Perucca E. Pharmacokinetic profile of topiramate in comparison with other new antiepileptic drugs. Epilepsia. 1996;37 Suppl 2:S8-S13.
Perucca, E. (1996). Pharmacokinetic profile of topiramate in comparison with other new antiepileptic drugs. Epilepsia, 37 Suppl 2, S8-S13.
Perucca E. Pharmacokinetic Profile of Topiramate in Comparison With Other New Antiepileptic Drugs. Epilepsia. 1996;37 Suppl 2:S8-S13. PubMed PMID: 8641245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetic profile of topiramate in comparison with other new antiepileptic drugs. A1 - Perucca,E, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - S8 EP - S13 JF - Epilepsia JO - Epilepsia VL - 37 Suppl 2 N2 - Antiepileptic drugs (AEDs) in broad use today have a number of pharmacokinetic liabilities, including a propensity for clinically meaningful drug interactions. Therefore, new AEDs with improved pharmacokinetic characteristics would be welcomed. The pharmacokinetic profiles of six newer AEDs--topiramate (TPM), gabapentin (GBP), vigabatrin (VGB), lamotrigine (LTG), oxcarbazepine (OCBZ), and felbamate--were reviewed. Some of these AEDs offer an improvement in one or more pharmacokinetic parameters compared with traditional AEDs, with TPM, GBP, VGB, and OCBZ demonstrating the most advantageous overall pharmacokinetic profiles. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/8641245/Pharmacokinetic_profile_of_topiramate_in_comparison_with_other_new_antiepileptic_drugs_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0013-9580&date=1996&volume=37&issue=&spage=S8 DB - PRIME DP - Unbound Medicine ER -