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Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women.
Am J Hum Genet 1996; 58(4):803-11AJ

Abstract

Late-onset Alzheimer disease (AD) is associated with the apolipoprotein E (APOE)-epsilon4 allele. In late-onset familial AD, women have a significantly higher risk of developing the disease than do men. The aim of this study was to determine whether the gender difference in familial AD is a function of APOE genotype. We studied 58 late-onset familial AD kindreds. Kaplan-Meier survival analysis was used to assess genotype-specific distributions of age at onset. Odds ratios were estimated by logistic regression with adjustment for age and by conditional logistic regression with stratification on families. All methods detected a significant gender difference for the epsilon4 heterozygous genotype. In women, epsilon4 heterozygotes had higher risk than those without epsilon4; there was no significant difference between epsilon4 heterozygotes and epsilon4 homozygotes. In men, epsilon4 heterozygotes had lower risk than epsilon4 homozygotes; there was not significant difference between epsilon4 heterozygotes and those without epsilon4. A direct comparison of epsilon4 heterozygous men and women revealed a significant twofold increased risk in women. We confirmed these results in 15 autopsy-confirmed AD kindreds from the National Cell Repository at Indiana University Alzheimer Disease Center. These observations are consistent with the increased incidence of familial AD in women and may be a critical clue to the role of gender in the pathogenesis of AD.

Authors+Show Affiliations

Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland, Oregon 97201, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8644745

Citation

Payami, H, et al. "Gender Difference in Apolipoprotein E-associated Risk for Familial Alzheimer Disease: a Possible Clue to the Higher Incidence of Alzheimer Disease in Women." American Journal of Human Genetics, vol. 58, no. 4, 1996, pp. 803-11.
Payami H, Zareparsi S, Montee KR, et al. Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. Am J Hum Genet. 1996;58(4):803-11.
Payami, H., Zareparsi, S., Montee, K. R., Sexton, G. J., Kaye, J. A., Bird, T. D., ... Schellenberg, G. D. (1996). Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. American Journal of Human Genetics, 58(4), pp. 803-11.
Payami H, et al. Gender Difference in Apolipoprotein E-associated Risk for Familial Alzheimer Disease: a Possible Clue to the Higher Incidence of Alzheimer Disease in Women. Am J Hum Genet. 1996;58(4):803-11. PubMed PMID: 8644745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. AU - Payami,H, AU - Zareparsi,S, AU - Montee,K R, AU - Sexton,G J, AU - Kaye,J A, AU - Bird,T D, AU - Yu,C E, AU - Wijsman,E M, AU - Heston,L L, AU - Litt,M, AU - Schellenberg,G D, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 803 EP - 11 JF - American journal of human genetics JO - Am. J. Hum. Genet. VL - 58 IS - 4 N2 - Late-onset Alzheimer disease (AD) is associated with the apolipoprotein E (APOE)-epsilon4 allele. In late-onset familial AD, women have a significantly higher risk of developing the disease than do men. The aim of this study was to determine whether the gender difference in familial AD is a function of APOE genotype. We studied 58 late-onset familial AD kindreds. Kaplan-Meier survival analysis was used to assess genotype-specific distributions of age at onset. Odds ratios were estimated by logistic regression with adjustment for age and by conditional logistic regression with stratification on families. All methods detected a significant gender difference for the epsilon4 heterozygous genotype. In women, epsilon4 heterozygotes had higher risk than those without epsilon4; there was no significant difference between epsilon4 heterozygotes and epsilon4 homozygotes. In men, epsilon4 heterozygotes had lower risk than epsilon4 homozygotes; there was not significant difference between epsilon4 heterozygotes and those without epsilon4. A direct comparison of epsilon4 heterozygous men and women revealed a significant twofold increased risk in women. We confirmed these results in 15 autopsy-confirmed AD kindreds from the National Cell Repository at Indiana University Alzheimer Disease Center. These observations are consistent with the increased incidence of familial AD in women and may be a critical clue to the role of gender in the pathogenesis of AD. SN - 0002-9297 UR - https://www.unboundmedicine.com/medline/citation/8644745/Gender_difference_in_apolipoprotein_E_associated_risk_for_familial_Alzheimer_disease:_a_possible_clue_to_the_higher_incidence_of_Alzheimer_disease_in_women_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8644745/ DB - PRIME DP - Unbound Medicine ER -