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[Zieve's syndrome. A case report].
Rev Esp Enferm Dig. 1996 Mar; 88(3):226-9.RE

Abstract

We report a case of Zieve's Syndrome that developed after an important alcohol consumption in a 32-yr-old female patient. She was admitted to the hospital with anorexia, asthenia and jaundice. Physical examination showed liver stigmata and hepatomegaly. Laboratory tests demonstrated increased aminotransferase levels, hyperbilirubinemia, hyperlipidemia and normocytic and normochromic anemia with dianocytes in peripheral blood smear. Ultrasonography showed a hyperechoic liver and a liver biopsy showed acute and chronic alcoholic liver disease. Clinical evolution was satisfactory and the therapy consisted of blood transfusion, parenteral fluids, B-complex vitamin and a fatty free diet. Jaundice, hyperlipidemia and haemolytic anemia define Zieve's Syndrome (Z.S.) There is a pathogenetic relationship among the clinical and biological phenomena in this syndrome, whose starter is an acute alcohol intake. Haemolysis is the distinctive feature with respect to the classical acute alcoholic hepatitis, and it is due to erythrocyte's metabolic and osmotic instability in relation to lipids abnormalities. Its clinical resolution precedes the normalization of serum lipids levels. Therapy is similar to that for acute alcoholic hepatitis although sometimes the anemia requires blood transfusion.

Authors+Show Affiliations

Servicio de Aparato Digestivo, Hospital Universitario Virgen Macarena, Sevilla.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Comparative Study
English Abstract
Journal Article

Language

spa

PubMed ID

8645520

Citation

Fernández Pérez, F J., et al. "[Zieve's Syndrome. a Case Report]." Revista Espanola De Enfermedades Digestivas : Organo Oficial De La Sociedad Espanola De Patologia Digestiva, vol. 88, no. 3, 1996, pp. 226-9.
Fernández Pérez FJ, Pallarés Manrique H, Cabello Ramírez M, et al. [Zieve's syndrome. A case report]. Rev Esp Enferm Dig. 1996;88(3):226-9.
Fernández Pérez, F. J., Pallarés Manrique, H., Cabello Ramírez, M., Piñar Moreno, A. L., Rebollo Bernárdez, J., Jiménez Sáenz, M., & Herrerías Gutiérrez, J. M. (1996). [Zieve's syndrome. A case report]. Revista Espanola De Enfermedades Digestivas : Organo Oficial De La Sociedad Espanola De Patologia Digestiva, 88(3), 226-9.
Fernández Pérez FJ, et al. [Zieve's Syndrome. a Case Report]. Rev Esp Enferm Dig. 1996;88(3):226-9. PubMed PMID: 8645520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Zieve's syndrome. A case report]. AU - Fernández Pérez,F J, AU - Pallarés Manrique,H, AU - Cabello Ramírez,M, AU - Piñar Moreno,A L, AU - Rebollo Bernárdez,J, AU - Jiménez Sáenz,M, AU - Herrerías Gutiérrez,J M, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 226 EP - 9 JF - Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva JO - Rev Esp Enferm Dig VL - 88 IS - 3 N2 - We report a case of Zieve's Syndrome that developed after an important alcohol consumption in a 32-yr-old female patient. She was admitted to the hospital with anorexia, asthenia and jaundice. Physical examination showed liver stigmata and hepatomegaly. Laboratory tests demonstrated increased aminotransferase levels, hyperbilirubinemia, hyperlipidemia and normocytic and normochromic anemia with dianocytes in peripheral blood smear. Ultrasonography showed a hyperechoic liver and a liver biopsy showed acute and chronic alcoholic liver disease. Clinical evolution was satisfactory and the therapy consisted of blood transfusion, parenteral fluids, B-complex vitamin and a fatty free diet. Jaundice, hyperlipidemia and haemolytic anemia define Zieve's Syndrome (Z.S.) There is a pathogenetic relationship among the clinical and biological phenomena in this syndrome, whose starter is an acute alcohol intake. Haemolysis is the distinctive feature with respect to the classical acute alcoholic hepatitis, and it is due to erythrocyte's metabolic and osmotic instability in relation to lipids abnormalities. Its clinical resolution precedes the normalization of serum lipids levels. Therapy is similar to that for acute alcoholic hepatitis although sometimes the anemia requires blood transfusion. SN - 1130-0108 UR - https://www.unboundmedicine.com/medline/citation/8645520/[Zieve's_syndrome._A_case_report]. DB - PRIME DP - Unbound Medicine ER -