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Liver-specific and shared cell membrane antigens. Studies by light- and electron microscopy.
Immunology. 1978 Aug; 35(2):289-98.I

Abstract

Liver-specific and shared saline-insoluble cell surface antigens were localized by immunofluorescence as well as by light- and electron microscopic immunoenzyme techniques. Antisera against purified mouse liver cell membranes were surface membrane but not organ-specific. Variable quantities of shared antigens were present in endoderm- and mesoderm-derived organs but not in ectodermal nerve tissue. Species crossreactivity was observed for the rat. Repeated absorption produced liver-specific antisera that reacted with antigenic sites distributed along the entire hepatocyte and sinusoidal cell surfaces. For the precise localization as well as the detection of low concentrations of both liver-specific and nonspecific antigens, the ultrastructural visualization of reactive sites proved essential.

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Authors

Behrens UJ
No affiliation info available
Paronetto F
No affiliation info available

MeSH

AnimalsAntigens, SurfaceCell MembraneCross ReactionsEpitopesFemaleFluorescent Antibody TechniqueImmune SeraImmunoenzyme TechniquesLiverMiceMice, Inbred AKRMicroscopy, ElectronRats

Pub Type(s)

Journal Article

Language

eng

PubMed ID

86503

Citation

Behrens, U J., and F Paronetto. "Liver-specific and Shared Cell Membrane Antigens. Studies By Light- and Electron Microscopy." Immunology, vol. 35, no. 2, 1978, pp. 289-98.
Behrens UJ, Paronetto F. Liver-specific and shared cell membrane antigens. Studies by light- and electron microscopy. Immunology. 1978;35(2):289-98.
Behrens, U. J., & Paronetto, F. (1978). Liver-specific and shared cell membrane antigens. Studies by light- and electron microscopy. Immunology, 35(2), 289-98.
Behrens UJ, Paronetto F. Liver-specific and Shared Cell Membrane Antigens. Studies By Light- and Electron Microscopy. Immunology. 1978;35(2):289-98. PubMed PMID: 86503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver-specific and shared cell membrane antigens. Studies by light- and electron microscopy. AU - Behrens,U J, AU - Paronetto,F, PY - 1978/8/1/pubmed PY - 1978/8/1/medline PY - 1978/8/1/entrez SP - 289 EP - 98 JF - Immunology JO - Immunology VL - 35 IS - 2 N2 - Liver-specific and shared saline-insoluble cell surface antigens were localized by immunofluorescence as well as by light- and electron microscopic immunoenzyme techniques. Antisera against purified mouse liver cell membranes were surface membrane but not organ-specific. Variable quantities of shared antigens were present in endoderm- and mesoderm-derived organs but not in ectodermal nerve tissue. Species crossreactivity was observed for the rat. Repeated absorption produced liver-specific antisera that reacted with antigenic sites distributed along the entire hepatocyte and sinusoidal cell surfaces. For the precise localization as well as the detection of low concentrations of both liver-specific and nonspecific antigens, the ultrastructural visualization of reactive sites proved essential. SN - 0019-2805 UR - https://www.unboundmedicine.com/medline/citation/86503/Liver_specific_and_shared_cell_membrane_antigens__Studies_by_light__and_electron_microscopy_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/86503/ DB - PRIME DP - Unbound Medicine ER -