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Horizontal versus vertical transmission of human immunodeficiency virus type 1 (HIV-1). Experience from southwestern Saudi Arabia.
Trop Geogr Med. 1995; 47(6):293-5.TG

Abstract

Twenty-five confirmed cases of human immunodeficiency virus type 1 (HIV-1) infection due to blood transfusion have been documented at King Fahad Hospital (KFH) in Al-Baha, southwestern Saudi Arabia since 1986, but complete follow-up was only possible on 19 of these cases and their contacts. Seventeen cases were diagnosed as having acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) after admission to the hospital due to the deterioration of their health status. Two cases were found to be anti-HIV-1 positive on routine screening for blood donation. This cluster of HIV-1 infected patients through blood transfusion allowed us to study the efficiency of sexual transmission of HIV-1 infection between spouses, the rate of perinatal transmission of HIV-1 infection, and to see whether intrafamilial transmission is a possible route of spread of the virus. Firstly, the present results confirm our earlier observation that transmission of HIV-1 infection was more efficient from the infected husband to his wife(s) in contrast to the inefficient transmission of the infection from the infected wife to her husband. Secondly, by the age of 16 months, all nine newborns to HIV-1 infected mothers became HIV-1 infected. This highlights the importance of medical advice to those mothers regarding conception and/or breast-feeding, particularly as breast-feeding up to 2 years is not an uncommon practice among Saudi women. Finally, none of the household contacts of the 19 cases was infected until now, indicating that intrafamilial spread of HIV-1 did not occur among the population studied.

Authors+Show Affiliations

Department of Medicine, King Fahad Hospital, Al-Baha, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8650743

Citation

al-Nozha, M M., et al. "Horizontal Versus Vertical Transmission of Human Immunodeficiency Virus Type 1 (HIV-1). Experience From Southwestern Saudi Arabia." Tropical and Geographical Medicine, vol. 47, no. 6, 1995, pp. 293-5.
al-Nozha MM, al-Frayh AR, al-Nasser M, et al. Horizontal versus vertical transmission of human immunodeficiency virus type 1 (HIV-1). Experience from southwestern Saudi Arabia. Trop Geogr Med. 1995;47(6):293-5.
al-Nozha, M. M., al-Frayh, A. R., al-Nasser, M., & Ramia, S. (1995). Horizontal versus vertical transmission of human immunodeficiency virus type 1 (HIV-1). Experience from southwestern Saudi Arabia. Tropical and Geographical Medicine, 47(6), 293-5.
al-Nozha MM, et al. Horizontal Versus Vertical Transmission of Human Immunodeficiency Virus Type 1 (HIV-1). Experience From Southwestern Saudi Arabia. Trop Geogr Med. 1995;47(6):293-5. PubMed PMID: 8650743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Horizontal versus vertical transmission of human immunodeficiency virus type 1 (HIV-1). Experience from southwestern Saudi Arabia. AU - al-Nozha,M M, AU - al-Frayh,A R, AU - al-Nasser,M, AU - Ramia,S, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez KW - Arab Countries KW - Asia KW - Blood Transfusion KW - Developing Countries KW - Diseases KW - Examinations And Diagnoses KW - Follow-up Studies KW - Hiv Infections--transmission KW - Hiv Serodiagnosis KW - Laboratory Examinations And Diagnoses KW - Research Methodology KW - Research Report KW - Saudi Arabia KW - Studies KW - Treatment KW - Vertical Transmission KW - Viral Diseases KW - Western Asia SP - 293 EP - 5 JF - Tropical and geographical medicine JO - Trop Geogr Med VL - 47 IS - 6 N2 - Twenty-five confirmed cases of human immunodeficiency virus type 1 (HIV-1) infection due to blood transfusion have been documented at King Fahad Hospital (KFH) in Al-Baha, southwestern Saudi Arabia since 1986, but complete follow-up was only possible on 19 of these cases and their contacts. Seventeen cases were diagnosed as having acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) after admission to the hospital due to the deterioration of their health status. Two cases were found to be anti-HIV-1 positive on routine screening for blood donation. This cluster of HIV-1 infected patients through blood transfusion allowed us to study the efficiency of sexual transmission of HIV-1 infection between spouses, the rate of perinatal transmission of HIV-1 infection, and to see whether intrafamilial transmission is a possible route of spread of the virus. Firstly, the present results confirm our earlier observation that transmission of HIV-1 infection was more efficient from the infected husband to his wife(s) in contrast to the inefficient transmission of the infection from the infected wife to her husband. Secondly, by the age of 16 months, all nine newborns to HIV-1 infected mothers became HIV-1 infected. This highlights the importance of medical advice to those mothers regarding conception and/or breast-feeding, particularly as breast-feeding up to 2 years is not an uncommon practice among Saudi women. Finally, none of the household contacts of the 19 cases was infected until now, indicating that intrafamilial spread of HIV-1 did not occur among the population studied. SN - 0041-3232 UR - https://www.unboundmedicine.com/medline/citation/8650743/Horizontal_versus_vertical_transmission_of_human_immunodeficiency_virus_type_1__HIV_1___Experience_from_southwestern_Saudi_Arabia_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -