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Evaluation of the pathogenesis of flatulence and abdominal cramps in patients with lactose malabsorption.
Wien Klin Wochenschr. 1996; 108(6):175-9.WK

Abstract

Aim of this study was to assess whether the interindividual differences in the development of flatulence and cramps in patients with lactose malabsorption are due to the quantity of malabsorbed lactose or gas accumulation, or if accelerated intestinal transit or increased perception of gas might play a role. Hydrogen breath tests were performed in 43 patients with lactose malabsorption after ingestion of 50 g lactose and, on a separate day, 25 g lactulose. The unabsorbed amount of lactose, small bowel transit time and colonic hydrogen accumulation were assessed in patients who did and did not develop flatulence and cramps after ingestion of lactose. The unabsorbed amount of lactose, small bowel transit time and volume and rate of colonic hydrogen accumulation were the same in patients who did or did not have symptoms after lactose. Patients with flatulence and cramps had a significantly longer time interval between the onset of the increase and peak breath hydrogen concentration (p < 0.05) and a significant correlation between the time of occurrence of peak symptoms and the time of peak breath hydrogen concentration (r = 0.75, p < 0.001). Our data suggest that subjective symptoms of lactose intolerance are not due to the amount of malabsorbed lactose or to the volume or rate of gas accumulation per se, but are related to increased perception of gas.

Authors+Show Affiliations

Medizinische Universitätsklinik, Graz.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8650927

Citation

Hammer, H F., et al. "Evaluation of the Pathogenesis of Flatulence and Abdominal Cramps in Patients With Lactose Malabsorption." Wiener Klinische Wochenschrift, vol. 108, no. 6, 1996, pp. 175-9.
Hammer HF, Petritsch W, Pristautz H, et al. Evaluation of the pathogenesis of flatulence and abdominal cramps in patients with lactose malabsorption. Wien Klin Wochenschr. 1996;108(6):175-9.
Hammer, H. F., Petritsch, W., Pristautz, H., & Krejs, G. J. (1996). Evaluation of the pathogenesis of flatulence and abdominal cramps in patients with lactose malabsorption. Wiener Klinische Wochenschrift, 108(6), 175-9.
Hammer HF, et al. Evaluation of the Pathogenesis of Flatulence and Abdominal Cramps in Patients With Lactose Malabsorption. Wien Klin Wochenschr. 1996;108(6):175-9. PubMed PMID: 8650927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the pathogenesis of flatulence and abdominal cramps in patients with lactose malabsorption. AU - Hammer,H F, AU - Petritsch,W, AU - Pristautz,H, AU - Krejs,G J, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 175 EP - 9 JF - Wiener klinische Wochenschrift JO - Wien Klin Wochenschr VL - 108 IS - 6 N2 - Aim of this study was to assess whether the interindividual differences in the development of flatulence and cramps in patients with lactose malabsorption are due to the quantity of malabsorbed lactose or gas accumulation, or if accelerated intestinal transit or increased perception of gas might play a role. Hydrogen breath tests were performed in 43 patients with lactose malabsorption after ingestion of 50 g lactose and, on a separate day, 25 g lactulose. The unabsorbed amount of lactose, small bowel transit time and colonic hydrogen accumulation were assessed in patients who did and did not develop flatulence and cramps after ingestion of lactose. The unabsorbed amount of lactose, small bowel transit time and volume and rate of colonic hydrogen accumulation were the same in patients who did or did not have symptoms after lactose. Patients with flatulence and cramps had a significantly longer time interval between the onset of the increase and peak breath hydrogen concentration (p < 0.05) and a significant correlation between the time of occurrence of peak symptoms and the time of peak breath hydrogen concentration (r = 0.75, p < 0.001). Our data suggest that subjective symptoms of lactose intolerance are not due to the amount of malabsorbed lactose or to the volume or rate of gas accumulation per se, but are related to increased perception of gas. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/8650927/Evaluation_of_the_pathogenesis_of_flatulence_and_abdominal_cramps_in_patients_with_lactose_malabsorption_ L2 - https://medlineplus.gov/gas.html DB - PRIME DP - Unbound Medicine ER -