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Severe recurrent hepatic encephalopathy that responded to oral branched chain amino acids.
Am J Gastroenterol 1996; 91(6):1266-8AJ

Abstract

Hepatic encephalopathy is a neuropsychiatric syndrome occurring in patients with acute or chronic liver disease. Its pathogenesis remains unclear; however, it appears to be multifactorial. There are several conventional treatments for this condition, such as lactulose, neomycin, and protein restriction. There is significant controversy regarding the role of branched chain amino acids in the treatment of chronic hepatic encephalopathy. We describe a patient who had hepatic encephalopathy secondary to Budd-Chairi syndrome and a mesoatrial shunt that failed vigorous conventional therapy. She required multiple hospitalizations for severe recurrent encephalopathy. The patient was considered for a colonic exclusion procedure for the management of intractable encephalopathy. However, branched amino acid therapy was instituted as a last measure before the contemplated surgery, and the patient's encephalopathy responded in dramatic fashion, and she remained free from encephalopathy during a prolonged follow-up.

Authors+Show Affiliations

Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA.No affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

8651189

Citation

Chalasani, N, and N Gitlin. "Severe Recurrent Hepatic Encephalopathy That Responded to Oral Branched Chain Amino Acids." The American Journal of Gastroenterology, vol. 91, no. 6, 1996, pp. 1266-8.
Chalasani N, Gitlin N. Severe recurrent hepatic encephalopathy that responded to oral branched chain amino acids. Am J Gastroenterol. 1996;91(6):1266-8.
Chalasani, N., & Gitlin, N. (1996). Severe recurrent hepatic encephalopathy that responded to oral branched chain amino acids. The American Journal of Gastroenterology, 91(6), pp. 1266-8.
Chalasani N, Gitlin N. Severe Recurrent Hepatic Encephalopathy That Responded to Oral Branched Chain Amino Acids. Am J Gastroenterol. 1996;91(6):1266-8. PubMed PMID: 8651189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe recurrent hepatic encephalopathy that responded to oral branched chain amino acids. AU - Chalasani,N, AU - Gitlin,N, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 1266 EP - 8 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 91 IS - 6 N2 - Hepatic encephalopathy is a neuropsychiatric syndrome occurring in patients with acute or chronic liver disease. Its pathogenesis remains unclear; however, it appears to be multifactorial. There are several conventional treatments for this condition, such as lactulose, neomycin, and protein restriction. There is significant controversy regarding the role of branched chain amino acids in the treatment of chronic hepatic encephalopathy. We describe a patient who had hepatic encephalopathy secondary to Budd-Chairi syndrome and a mesoatrial shunt that failed vigorous conventional therapy. She required multiple hospitalizations for severe recurrent encephalopathy. The patient was considered for a colonic exclusion procedure for the management of intractable encephalopathy. However, branched amino acid therapy was instituted as a last measure before the contemplated surgery, and the patient's encephalopathy responded in dramatic fashion, and she remained free from encephalopathy during a prolonged follow-up. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/8651189/Severe_recurrent_hepatic_encephalopathy_that_responded_to_oral_branched_chain_amino_acids_ L2 - http://www.diseaseinfosearch.org/result/3328 DB - PRIME DP - Unbound Medicine ER -