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Alzheimer's disease and apolipoprotein E-4 allele in an Amish population.
Ann Neurol. 1996 Jun; 39(6):700-4.AN

Abstract

Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and presenilin II, cause early-onset AD. The apolipoprotein E (APOE) gene contributes primarily to late-onset AD. The APOE-4 allele acts in a dose-related fashion to increase risk and decrease the age-of-onset distribution in AD. We examined the effect of APOE on AD in a previously unstudied Amish population that has a lower prevalence of dementia compared with other populations. We sampled a large inbred family with 6 late-onset AD members. We also genotyped 53 individuals from the general Amish population as controls for the APOE allele frequency estimates. The frequency of the APOE-4 allele in the Amish controls was 0.037 +/- 0.02. This differed significantly compared with three independent sets of non-Amish white controls (p < 2 x 10(-4), p < 6 x 10(-5), and p < 2 x 10(-6)). In addition, all Amish AD-affected individuals had APOE 3/3 genotypes; no APOE X/4 or 4/4 individuals were observed. We suggest that the lower frequency of dementia in the Amish may be partially explained by the decreased frequency of the APOE-4 allele in this population, and that the inbred nature of this pedigree, with its strong clustering of cases contrasted against the lower frequency of dementia, indicates that additional genetic factors influence late-onset AD.

Authors+Show Affiliations

Duke University Medical Center, Department of Medicine, Division of Neurology, Durham, NC 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8651641

Citation

Pericak-Vance, M A., et al. "Alzheimer's Disease and Apolipoprotein E-4 Allele in an Amish Population." Annals of Neurology, vol. 39, no. 6, 1996, pp. 700-4.
Pericak-Vance MA, Johnson CC, Rimmler JB, et al. Alzheimer's disease and apolipoprotein E-4 allele in an Amish population. Ann Neurol. 1996;39(6):700-4.
Pericak-Vance, M. A., Johnson, C. C., Rimmler, J. B., Saunders, A. M., Robinson, L. C., D'Hondt, E. G., Jackson, C. E., & Haines, J. L. (1996). Alzheimer's disease and apolipoprotein E-4 allele in an Amish population. Annals of Neurology, 39(6), 700-4.
Pericak-Vance MA, et al. Alzheimer's Disease and Apolipoprotein E-4 Allele in an Amish Population. Ann Neurol. 1996;39(6):700-4. PubMed PMID: 8651641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alzheimer's disease and apolipoprotein E-4 allele in an Amish population. AU - Pericak-Vance,M A, AU - Johnson,C C, AU - Rimmler,J B, AU - Saunders,A M, AU - Robinson,L C, AU - D'Hondt,E G, AU - Jackson,C E, AU - Haines,J L, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 700 EP - 4 JF - Annals of neurology JO - Ann. Neurol. VL - 39 IS - 6 N2 - Alzheimer's Disease (AD) is a complex genetic disorder with four loci already identified. Mutations in three of these, the amyloid precursor protein, presenilin I, and presenilin II, cause early-onset AD. The apolipoprotein E (APOE) gene contributes primarily to late-onset AD. The APOE-4 allele acts in a dose-related fashion to increase risk and decrease the age-of-onset distribution in AD. We examined the effect of APOE on AD in a previously unstudied Amish population that has a lower prevalence of dementia compared with other populations. We sampled a large inbred family with 6 late-onset AD members. We also genotyped 53 individuals from the general Amish population as controls for the APOE allele frequency estimates. The frequency of the APOE-4 allele in the Amish controls was 0.037 +/- 0.02. This differed significantly compared with three independent sets of non-Amish white controls (p < 2 x 10(-4), p < 6 x 10(-5), and p < 2 x 10(-6)). In addition, all Amish AD-affected individuals had APOE 3/3 genotypes; no APOE X/4 or 4/4 individuals were observed. We suggest that the lower frequency of dementia in the Amish may be partially explained by the decreased frequency of the APOE-4 allele in this population, and that the inbred nature of this pedigree, with its strong clustering of cases contrasted against the lower frequency of dementia, indicates that additional genetic factors influence late-onset AD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8651641/Alzheimer's_disease_and_apolipoprotein_E_4_allele_in_an_Amish_population_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0364-5134&amp;date=1996&amp;volume=39&amp;issue=6&amp;spage=700 DB - PRIME DP - Unbound Medicine ER -