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DPC4 gene in various tumor types.
Cancer Res 1996; 56(11):2527-30CR

Abstract

We recently identified a novel tumor-suppressor gene, DPC4, at chromosome 18q21.1 and found that both alleles of DPC4 were inactivated in nearly one-half of the pancreatic carcinomas. Here, we analyzed 338 tumors, originating from 12 distinct anatomic sites, for alterations in the DPC4 gene. Sixty-four specimens were selected for the presence of the allelic loss of 18q and were further analyzed for DPC4 sequence alterations. An alteration of the DPC4 gene sequence was identified in one of eight breast carcinomas and one of eight ovarian carcinomas. These results indicate that whereas DPC4 inactivation is prevalent in pancreatic carcinoma (48%), it is distinctly uncommon (< 10%) in the other tumor types examined. The tissue restriction of alterations in DPC4, as in many other tumor-suppressor genes, emphasizes the complexity of rate-limiting checkpoints in human tumorigenesis.

Authors+Show Affiliations

Gepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205-2196, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8653691

Citation

Schutte, M, et al. "DPC4 Gene in Various Tumor Types." Cancer Research, vol. 56, no. 11, 1996, pp. 2527-30.
Schutte M, Hruban RH, Hedrick L, et al. DPC4 gene in various tumor types. Cancer Res. 1996;56(11):2527-30.
Schutte, M., Hruban, R. H., Hedrick, L., Cho, K. R., Nadasdy, G. M., Weinstein, C. L., ... Kern, S. E. (1996). DPC4 gene in various tumor types. Cancer Research, 56(11), pp. 2527-30.
Schutte M, et al. DPC4 Gene in Various Tumor Types. Cancer Res. 1996 Jun 1;56(11):2527-30. PubMed PMID: 8653691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DPC4 gene in various tumor types. AU - Schutte,M, AU - Hruban,R H, AU - Hedrick,L, AU - Cho,K R, AU - Nadasdy,G M, AU - Weinstein,C L, AU - Bova,G S, AU - Isaacs,W B, AU - Cairns,P, AU - Nawroz,H, AU - Sidransky,D, AU - Casero,R A,Jr AU - Meltzer,P S, AU - Hahn,S A, AU - Kern,S E, PY - 1996/6/1/pubmed PY - 2001/3/28/medline PY - 1996/6/1/entrez SP - 2527 EP - 30 JF - Cancer research JO - Cancer Res. VL - 56 IS - 11 N2 - We recently identified a novel tumor-suppressor gene, DPC4, at chromosome 18q21.1 and found that both alleles of DPC4 were inactivated in nearly one-half of the pancreatic carcinomas. Here, we analyzed 338 tumors, originating from 12 distinct anatomic sites, for alterations in the DPC4 gene. Sixty-four specimens were selected for the presence of the allelic loss of 18q and were further analyzed for DPC4 sequence alterations. An alteration of the DPC4 gene sequence was identified in one of eight breast carcinomas and one of eight ovarian carcinomas. These results indicate that whereas DPC4 inactivation is prevalent in pancreatic carcinoma (48%), it is distinctly uncommon (< 10%) in the other tumor types examined. The tissue restriction of alterations in DPC4, as in many other tumor-suppressor genes, emphasizes the complexity of rate-limiting checkpoints in human tumorigenesis. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/8653691/DPC4_gene_in_various_tumor_types_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=8653691 DB - PRIME DP - Unbound Medicine ER -