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Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis.
J Allergy Clin Immunol. 1996 Apr; 97(4):915-21.JA

Abstract

BACKGROUND

Comparative studies with topical corticosteroids and antihistamines for treatment of allergic rhinitis have not always demonstrated clear distinctions between the two on the basis of therapeutic efficacy.

OBJECTIVE

This study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray with those of terfenadine in the treatment of seasonal allergic rhinitis.

METHODS

Three hundred forty-eight patients with allergic rhinitis were given fluticasone propionate aqueous nasal spray (200 micrograms once daily), terfenadine tablets (60 mg twice daily), or placebo for 4 weeks in a multicenter, randomized, double-blind, double-dummy, parallel-group study.

RESULTS

Clinician-rated total nasal symptom scores after 1, 2, 3, and 4 weeks of therapy and patient-rated total nasal symptom scores throughout treatment were significantly (p <0.05) lower in the fluticasone propionate group compared with the terfenadine group or the placebo group. Terfenadine was not statistically different from placebo on the basis of clinician-related nasal symptom scores, except for sneezing. Total nasal airflow, measured by rhinomanometry, significantly (p <0.05) improved in the fluticasone propionate group compared with the terfenadine group or the placebo group. More fluticasone propionate-treated patients compared with placebo-treated patients had reduced nasal mucosal eosinophil counts after 4 weeks of therapy (p <0.05). No serious or unusual drug-related adverse events were reported. Morning plasma cortisol concentrations after 4 weeks of therapy did not differ among groups.

CONCLUSION

Fluticasone propionate aqueous nasal spray is more effective than terfenadine tablets for treatment of seasonal allergic rhinitis.

Authors+Show Affiliations

AAAA Medical Research Group, Salt Lake City, UT 84102, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8655886

Citation

Bronsky, E A., et al. "Fluticasone Propionate Aqueous Nasal Spray Compared With Terfenadine Tablets in the Treatment of Seasonal Allergic Rhinitis." The Journal of Allergy and Clinical Immunology, vol. 97, no. 4, 1996, pp. 915-21.
Bronsky EA, Dockhorn RJ, Meltzer EO, et al. Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol. 1996;97(4):915-21.
Bronsky, E. A., Dockhorn, R. J., Meltzer, E. O., Shapiro, G., Boltansky, H., LaForce, C., Ransom, J., Weiler, J. M., Blumenthal, M., Weakley, S., Wisniewski, M., Field, E., & Rogenes, P. (1996). Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis. The Journal of Allergy and Clinical Immunology, 97(4), 915-21.
Bronsky EA, et al. Fluticasone Propionate Aqueous Nasal Spray Compared With Terfenadine Tablets in the Treatment of Seasonal Allergic Rhinitis. J Allergy Clin Immunol. 1996;97(4):915-21. PubMed PMID: 8655886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis. AU - Bronsky,E A, AU - Dockhorn,R J, AU - Meltzer,E O, AU - Shapiro,G, AU - Boltansky,H, AU - LaForce,C, AU - Ransom,J, AU - Weiler,J M, AU - Blumenthal,M, AU - Weakley,S, AU - Wisniewski,M, AU - Field,E, AU - Rogenes,P, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 915 EP - 21 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 97 IS - 4 N2 - BACKGROUND: Comparative studies with topical corticosteroids and antihistamines for treatment of allergic rhinitis have not always demonstrated clear distinctions between the two on the basis of therapeutic efficacy. OBJECTIVE: This study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray with those of terfenadine in the treatment of seasonal allergic rhinitis. METHODS: Three hundred forty-eight patients with allergic rhinitis were given fluticasone propionate aqueous nasal spray (200 micrograms once daily), terfenadine tablets (60 mg twice daily), or placebo for 4 weeks in a multicenter, randomized, double-blind, double-dummy, parallel-group study. RESULTS: Clinician-rated total nasal symptom scores after 1, 2, 3, and 4 weeks of therapy and patient-rated total nasal symptom scores throughout treatment were significantly (p <0.05) lower in the fluticasone propionate group compared with the terfenadine group or the placebo group. Terfenadine was not statistically different from placebo on the basis of clinician-related nasal symptom scores, except for sneezing. Total nasal airflow, measured by rhinomanometry, significantly (p <0.05) improved in the fluticasone propionate group compared with the terfenadine group or the placebo group. More fluticasone propionate-treated patients compared with placebo-treated patients had reduced nasal mucosal eosinophil counts after 4 weeks of therapy (p <0.05). No serious or unusual drug-related adverse events were reported. Morning plasma cortisol concentrations after 4 weeks of therapy did not differ among groups. CONCLUSION: Fluticasone propionate aqueous nasal spray is more effective than terfenadine tablets for treatment of seasonal allergic rhinitis. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/8655886/Fluticasone_propionate_aqueous_nasal_spray_compared_with_terfenadine_tablets_in_the_treatment_of_seasonal_allergic_rhinitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674996000905 DB - PRIME DP - Unbound Medicine ER -