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Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support.
J Am Diet Assoc. 1996 Jun; 96(6):565-9.JA

Abstract

OBJECTIVE

To determine whether certain nutrients and dietary factors act as modulators of the immune system and improve the nutritional status of immunocompromised patients.

DESIGN

Controlled, double-blind, crossover phase trials of the effects of a fortified formula in patients infected with the human immunodeficiency virus (HIV). Patients consumed a control formula for 4 months and a study formula for 4 months.

SUBJECTS

Ten men with symptomatic HIV infection who were following stable medication regimens and had no malignancies, mycobacteriosis, or additional virus infection requiring systemic treatment.

INTERVENTION

Formula fortified with alpha-linolenic acid (1.8 g/day), arginine (7.8 g/day), and RNA (0.75 g/day) and a standard formula.

MAIN OUTCOME MEASURES

Nutritional status determined by anthropometric, bioelectrical, biochemical, and dietary assessment; energy expenditure determined by indirect calorimetry; disease progression; CD4 lymphocyte counts; HIV p24 antigen plasma concentrations; tumor necrosis factor (TNF) receptor proteins; and compliance control parameters.

STATISTICAL ANALYSES PERFORMED

Student's t tests for paired and unpaired data.

RESULTS

Fortified nutrition resulted in a weight gain (+ 2.9 kg/4 months vs -0.5 kg/4 months with the control formula, P < .05), an incorporation of eicosaenoic acid into erythrocyte cell membranes (+ 47% of baseline values, P < .05), and increased plasma arginine concentrations (96.8 +/- 45.1 vs 51.8 +/- 20.9 mumol/L, P < .01). The serum concentrations of the soluble tumor necrosis factor receptor (sTNFR) proteins increased during the study period (sTNFR 55 = + 0.23 vs -0.40 ng/mL, P < .001; sTNFR 75 = + 0.90 vs -0.36 ng/mL, P < .01), whereas no changes in CD4+ lymphocyte counts were observed.

CONCLUSION

Increasing dietary intakes of n-3 polyunsaturated fatty acids, L-arginine, and RNA increased body weight, possibly by modulating the negative effects of TNF.

Links

Publisher Full Text

Authors+Show Affiliations

Süttmann U
Zentrum Innere Medizin und Dermatologie, Abteilung Klinische Immunologie, Lehrte, Germany.
Ockenga J
No affiliation info available
Schneider H
No affiliation info available
Selberg O
No affiliation info available
Schlesinger A
No affiliation info available
Gallati H
No affiliation info available
Wolfram G
No affiliation info available
Deicher H
No affiliation info available
Müller MJ
No affiliation info available

MeSH

AdolescentAdultAgedAnthropometryArginineCD4-Positive T-LymphocytesCross-Over StudiesDouble-Blind MethodEnergy MetabolismFood, FormulatedFood, FortifiedHIV AntigensHIV InfectionsHumansImmune SystemLinoleic AcidLinoleic AcidsMaleMiddle AgedNutritional StatusRNAReceptors, Tumor Necrosis FactorWeight Gain

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8655902

Citation

Süttmann, U, et al. "Weight Gain and Increased Concentrations of Receptor Proteins for Tumor Necrosis Factor After Patients With Symptomatic HIV Infection Received Fortified Nutrition Support." Journal of the American Dietetic Association, vol. 96, no. 6, 1996, pp. 565-9.
Süttmann U, Ockenga J, Schneider H, et al. Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support. J Am Diet Assoc. 1996;96(6):565-9.
Süttmann, U., Ockenga, J., Schneider, H., Selberg, O., Schlesinger, A., Gallati, H., Wolfram, G., Deicher, H., & Müller, M. J. (1996). Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support. Journal of the American Dietetic Association, 96(6), 565-9.
Süttmann U, et al. Weight Gain and Increased Concentrations of Receptor Proteins for Tumor Necrosis Factor After Patients With Symptomatic HIV Infection Received Fortified Nutrition Support. J Am Diet Assoc. 1996;96(6):565-9. PubMed PMID: 8655902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support. AU - Süttmann,U, AU - Ockenga,J, AU - Schneider,H, AU - Selberg,O, AU - Schlesinger,A, AU - Gallati,H, AU - Wolfram,G, AU - Deicher,H, AU - Müller,M J, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 565 EP - 9 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 96 IS - 6 N2 - OBJECTIVE: To determine whether certain nutrients and dietary factors act as modulators of the immune system and improve the nutritional status of immunocompromised patients. DESIGN: Controlled, double-blind, crossover phase trials of the effects of a fortified formula in patients infected with the human immunodeficiency virus (HIV). Patients consumed a control formula for 4 months and a study formula for 4 months. SUBJECTS: Ten men with symptomatic HIV infection who were following stable medication regimens and had no malignancies, mycobacteriosis, or additional virus infection requiring systemic treatment. INTERVENTION: Formula fortified with alpha-linolenic acid (1.8 g/day), arginine (7.8 g/day), and RNA (0.75 g/day) and a standard formula. MAIN OUTCOME MEASURES: Nutritional status determined by anthropometric, bioelectrical, biochemical, and dietary assessment; energy expenditure determined by indirect calorimetry; disease progression; CD4 lymphocyte counts; HIV p24 antigen plasma concentrations; tumor necrosis factor (TNF) receptor proteins; and compliance control parameters. STATISTICAL ANALYSES PERFORMED: Student's t tests for paired and unpaired data. RESULTS: Fortified nutrition resulted in a weight gain (+ 2.9 kg/4 months vs -0.5 kg/4 months with the control formula, P < .05), an incorporation of eicosaenoic acid into erythrocyte cell membranes (+ 47% of baseline values, P < .05), and increased plasma arginine concentrations (96.8 +/- 45.1 vs 51.8 +/- 20.9 mumol/L, P < .01). The serum concentrations of the soluble tumor necrosis factor receptor (sTNFR) proteins increased during the study period (sTNFR 55 = + 0.23 vs -0.40 ng/mL, P < .001; sTNFR 75 = + 0.90 vs -0.36 ng/mL, P < .01), whereas no changes in CD4+ lymphocyte counts were observed. CONCLUSION: Increasing dietary intakes of n-3 polyunsaturated fatty acids, L-arginine, and RNA increased body weight, possibly by modulating the negative effects of TNF. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/8655902/Weight_gain_and_increased_concentrations_of_receptor_proteins_for_tumor_necrosis_factor_after_patients_with_symptomatic_HIV_infection_received_fortified_nutrition_support_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(96)00156-3 DB - PRIME DP - Unbound Medicine ER -