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Testosterone maintenance therapy. Effects on vulvar lichen sclerosus treated with clobetasol propionate.
J Reprod Med. 1996 Feb; 41(2):99-102.JR

Abstract

OBJECTIVE

To evaluate the possible effects of topical testosterone as maintenance therapy after clobetasol propionate treatment.

STUDY DESIGN

Thirty-two patients with biopsy-proven vulvar lichen sclerosus (LS), after 24 weeks of treatment with 0.05% clobetasol propionate cream, were randomly distributed into two groups of 16 each and treated for a further length of time (24 weeks) with testosterone 2% ointment or a cream-based preparation (placebo). The patients were examined before and after treatment for symptoms, gross aspects and histologic features.

RESULTS

With clobetasol propionate all patients had a marked improvement (P < .001) in both clinical and histologic parameters. After clobetasol propionate therapy, the 16 testosterone-treated patients had significant worsening of their symptoms (P < .05%) and no evident changes in gross aspects (P = NS). The placebo-treated group had good symptomatic control of their disease, with no significant changes in symptoms or gross aspects (P = NS).

CONCLUSION

After the good results obtained with clobetasol propionate, treatment with testosterone appeared to have a negative effect, while a regularly provided emollient cream was useful in symptom control.

Authors+Show Affiliations

Cattaneo A
Institute of Gynecology and Obstetrics, University of Florence, Italy.
Carli P
No affiliation info available
De Marco A
No affiliation info available
Sonni L
No affiliation info available
Bracco G
No affiliation info available
De Magnis A
No affiliation info available
Taddei GL
No affiliation info available

MeSH

Administration, CutaneousAdultAgedAged, 80 and overBiopsyClobetasolDouble-Blind MethodDrug Therapy, CombinationFemaleHumansLichen Sclerosus et AtrophicusMiddle AgedSeverity of Illness IndexTestosteroneVulvar Lichen Sclerosus

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8656422

Citation

Cattaneo, A, et al. "Testosterone Maintenance Therapy. Effects On Vulvar Lichen Sclerosus Treated With Clobetasol Propionate." The Journal of Reproductive Medicine, vol. 41, no. 2, 1996, pp. 99-102.
Cattaneo A, Carli P, De Marco A, et al. Testosterone maintenance therapy. Effects on vulvar lichen sclerosus treated with clobetasol propionate. J Reprod Med. 1996;41(2):99-102.
Cattaneo, A., Carli, P., De Marco, A., Sonni, L., Bracco, G., De Magnis, A., & Taddei, G. L. (1996). Testosterone maintenance therapy. Effects on vulvar lichen sclerosus treated with clobetasol propionate. The Journal of Reproductive Medicine, 41(2), 99-102.
Cattaneo A, et al. Testosterone Maintenance Therapy. Effects On Vulvar Lichen Sclerosus Treated With Clobetasol Propionate. J Reprod Med. 1996;41(2):99-102. PubMed PMID: 8656422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Testosterone maintenance therapy. Effects on vulvar lichen sclerosus treated with clobetasol propionate. AU - Cattaneo,A, AU - Carli,P, AU - De Marco,A, AU - Sonni,L, AU - Bracco,G, AU - De Magnis,A, AU - Taddei,G L, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 99 EP - 102 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 41 IS - 2 N2 - OBJECTIVE: To evaluate the possible effects of topical testosterone as maintenance therapy after clobetasol propionate treatment. STUDY DESIGN: Thirty-two patients with biopsy-proven vulvar lichen sclerosus (LS), after 24 weeks of treatment with 0.05% clobetasol propionate cream, were randomly distributed into two groups of 16 each and treated for a further length of time (24 weeks) with testosterone 2% ointment or a cream-based preparation (placebo). The patients were examined before and after treatment for symptoms, gross aspects and histologic features. RESULTS: With clobetasol propionate all patients had a marked improvement (P < .001) in both clinical and histologic parameters. After clobetasol propionate therapy, the 16 testosterone-treated patients had significant worsening of their symptoms (P < .05%) and no evident changes in gross aspects (P = NS). The placebo-treated group had good symptomatic control of their disease, with no significant changes in symptoms or gross aspects (P = NS). CONCLUSION: After the good results obtained with clobetasol propionate, treatment with testosterone appeared to have a negative effect, while a regularly provided emollient cream was useful in symptom control. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/8656422/Testosterone_maintenance_therapy__Effects_on_vulvar_lichen_sclerosus_treated_with_clobetasol_propionate_ L2 - https://antibodies.cancer.gov/detail/CPTC-KRAS4B-1 DB - PRIME DP - Unbound Medicine ER -