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Transcutaneous oxygen tension in patients with and without pericapillary fibrin cuffs in chronic venous insufficiency, porphyria cutanea tarda and non-venous leg ulcers.
Vasa. 1996; 25(2):127-33.VASA

Abstract

To evaluate the influence of fibrin cuffs on the transcutaneous oxygen tension in patients with chronic venous insufficiency (CVI) we performed a prospective comparative study in an out-patient dermatological department of a district hospital in the Netherlands. 16 patients with CVI grade II or III, 6 patients with porphyria cutanea tarda (PCT) without any sign of CVI, 4 patients with clinical ecthyma type ulcers without CVI and 10 healthy volunteers were studied. Skin biopsies for fibrinogen staining, transcutaneous oxygen tension measurements (TcPO2) and light reflexion rheography (LRR) were performed. TcPO2 readings were significantly lower in patients with CVI compared to patients of the other groups. Fibrin cuffs were found in 8 out of 16 patients with CVI, all PCT patients and 3 out of 4 ecthyma-ulcer patients. On the basis of these results we conclude that the fibrin cuff alone does not act as a barrier for oxygen transport. Fibrin cuffs in CVI are not the cause of venous ulceration but only a part of the complicated mechanism of the altered microcirculation induced by reflux in the venous macrocirculation. Fibrin cuffs are not unique for CVI but an indication of a disturbed microcirculation.

Authors+Show Affiliations

Department of Dermatology, Academisch Ziekenhuis Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8659214

Citation

Neumann, H A., et al. "Transcutaneous Oxygen Tension in Patients With and Without Pericapillary Fibrin Cuffs in Chronic Venous Insufficiency, Porphyria Cutanea Tarda and Non-venous Leg Ulcers." VASA. Zeitschrift Fur Gefasskrankheiten, vol. 25, no. 2, 1996, pp. 127-33.
Neumann HA, van den Broek MJ, Boersma IH, et al. Transcutaneous oxygen tension in patients with and without pericapillary fibrin cuffs in chronic venous insufficiency, porphyria cutanea tarda and non-venous leg ulcers. Vasa. 1996;25(2):127-33.
Neumann, H. A., van den Broek, M. J., Boersma, I. H., & Veraart, J. C. (1996). Transcutaneous oxygen tension in patients with and without pericapillary fibrin cuffs in chronic venous insufficiency, porphyria cutanea tarda and non-venous leg ulcers. VASA. Zeitschrift Fur Gefasskrankheiten, 25(2), 127-33.
Neumann HA, et al. Transcutaneous Oxygen Tension in Patients With and Without Pericapillary Fibrin Cuffs in Chronic Venous Insufficiency, Porphyria Cutanea Tarda and Non-venous Leg Ulcers. Vasa. 1996;25(2):127-33. PubMed PMID: 8659214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcutaneous oxygen tension in patients with and without pericapillary fibrin cuffs in chronic venous insufficiency, porphyria cutanea tarda and non-venous leg ulcers. AU - Neumann,H A, AU - van den Broek,M J, AU - Boersma,I H, AU - Veraart,J C, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 127 EP - 33 JF - VASA. Zeitschrift fur Gefasskrankheiten JO - Vasa VL - 25 IS - 2 N2 - To evaluate the influence of fibrin cuffs on the transcutaneous oxygen tension in patients with chronic venous insufficiency (CVI) we performed a prospective comparative study in an out-patient dermatological department of a district hospital in the Netherlands. 16 patients with CVI grade II or III, 6 patients with porphyria cutanea tarda (PCT) without any sign of CVI, 4 patients with clinical ecthyma type ulcers without CVI and 10 healthy volunteers were studied. Skin biopsies for fibrinogen staining, transcutaneous oxygen tension measurements (TcPO2) and light reflexion rheography (LRR) were performed. TcPO2 readings were significantly lower in patients with CVI compared to patients of the other groups. Fibrin cuffs were found in 8 out of 16 patients with CVI, all PCT patients and 3 out of 4 ecthyma-ulcer patients. On the basis of these results we conclude that the fibrin cuff alone does not act as a barrier for oxygen transport. Fibrin cuffs in CVI are not the cause of venous ulceration but only a part of the complicated mechanism of the altered microcirculation induced by reflux in the venous macrocirculation. Fibrin cuffs are not unique for CVI but an indication of a disturbed microcirculation. SN - 0301-1526 UR - https://www.unboundmedicine.com/medline/citation/8659214/Transcutaneous_oxygen_tension_in_patients_with_and_without_pericapillary_fibrin_cuffs_in_chronic_venous_insufficiency_porphyria_cutanea_tarda_and_non_venous_leg_ulcers_ L2 - http://www.diseaseinfosearch.org/result/5879 DB - PRIME DP - Unbound Medicine ER -