Tags

Type your tag names separated by a space and hit enter

Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B.
Aust Vet J. 1996 Apr; 73(4):124-8.AV

Abstract

Six cases (3 cats, 3 dogs) of cryptococcosis were cured using combination chemotherapy that included amphotericin B. We developed a simple, practical and inexpensive method of administering amphotericin B as a subcutaneous infusion during the treatment of these patients. For this, the calculated dose of amphotericin B (0.5 to 0.8 mg/kg) was added to 400 mL, for cats, or to 500 mL, for dogs, of 0.45% saline containing 2.5% dextrose. These amounts were given subcutaneously 2 or 3 times weekly over several months, to a total cumulative dose of 8 to 26 mg/kg body weight. Subcutaneous infusions were generally well tolerated by the animals, although concentrations of amphotericin B in excess of 20 mg/L resulted in local irritation. This protocol enabled the administration of larger, and thus more effective, quantities of amphotericin B without producing marked azotaemia.

Links

Publisher Full Text

Authors+Show Affiliations

Malik R
Department of Veterinary Clinical Sciences, University of Sydney, New South Wales.
Craig AJ
No affiliation info available
Wigney DI
No affiliation info available
Martin P
No affiliation info available
Love DN
No affiliation info available

MeSH

Amphotericin BAnimalsAnti-Bacterial AgentsAntifungal AgentsCat DiseasesCatsCryptococcosisDog DiseasesDogsDrug Administration ScheduleDrug Therapy, CombinationFlucytosineInjections, SubcutaneousMaleTriazoles

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8660225

Citation

Malik, R, et al. "Combination Chemotherapy of Canine and Feline Cryptococcosis Using Subcutaneously Administered Amphotericin B." Australian Veterinary Journal, vol. 73, no. 4, 1996, pp. 124-8.
Malik R, Craig AJ, Wigney DI, et al. Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B. Aust Vet J. 1996;73(4):124-8.
Malik, R., Craig, A. J., Wigney, D. I., Martin, P., & Love, D. N. (1996). Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B. Australian Veterinary Journal, 73(4), 124-8.
Malik R, et al. Combination Chemotherapy of Canine and Feline Cryptococcosis Using Subcutaneously Administered Amphotericin B. Aust Vet J. 1996;73(4):124-8. PubMed PMID: 8660225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B. AU - Malik,R, AU - Craig,A J, AU - Wigney,D I, AU - Martin,P, AU - Love,D N, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 124 EP - 8 JF - Australian veterinary journal JO - Aust Vet J VL - 73 IS - 4 N2 - Six cases (3 cats, 3 dogs) of cryptococcosis were cured using combination chemotherapy that included amphotericin B. We developed a simple, practical and inexpensive method of administering amphotericin B as a subcutaneous infusion during the treatment of these patients. For this, the calculated dose of amphotericin B (0.5 to 0.8 mg/kg) was added to 400 mL, for cats, or to 500 mL, for dogs, of 0.45% saline containing 2.5% dextrose. These amounts were given subcutaneously 2 or 3 times weekly over several months, to a total cumulative dose of 8 to 26 mg/kg body weight. Subcutaneous infusions were generally well tolerated by the animals, although concentrations of amphotericin B in excess of 20 mg/L resulted in local irritation. This protocol enabled the administration of larger, and thus more effective, quantities of amphotericin B without producing marked azotaemia. SN - 0005-0423 UR - https://www.unboundmedicine.com/medline/citation/8660225/Combination_chemotherapy_of_canine_and_feline_cryptococcosis_using_subcutaneously_administered_amphotericin_B_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0005-0423&date=1996&volume=73&issue=4&spage=124 DB - PRIME DP - Unbound Medicine ER -