Tags

Type your tag names separated by a space and hit enter

A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2.
Genomics. 1996 Jun 01; 34(2):236-40.G

Abstract

CC chemokines are cytokines that attract and activate leukocytes. The human genes for the CC chemokines are clustered on chromosome 17. To elucidate the genomic organization of the CC chemokine genes, we constructed a YAC contig comprising 34 clones. The contig was shown to contain all 10 CC chemokine genes reported so far, except for one gene whose nucleotide sequence is not available. The contig also contains 4 CC chemokine-like genes, which were deposited in GenBank as ESTs and are here referred to as NCC-1, NCC-2, NCC-3, and NCC-4. Within the contig, the CC chemokine genes were localized in two regions. In addition, the CC chemokine genes were more precisely mapped on chromosome 17q11.2 using a somatic cell hybrid cell DNA panel containing various portions of human chromosome 17. Interestingly, a reciprocal translocation t(Y;17) breakpoint, contained in the hybrid cell line Y1741, lay between the two chromosome 17 chemokine gene regions covered by our YAC contig. From these results, the order and the orientation of CC chemokine genes on chromosome 17 were determined as follows: centromere-neurofibromatosis 1-(MCP-3, MCP-1, NCC-1, I-309)-Y1741 breakpoint-RANTES-(LD78gamma, AT744.2, LD78beta)-(NCC-3, NCC-2, AT744.1, LD78alpha)-NCC-4-retinoic acid receptor alpha- telomere.

Authors+Show Affiliations

Department of Biochemistry, Kumamoto University Medical School, Honjo 2-2-1, Kumamoto, 860, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8661057

Citation

Naruse, K, et al. "A YAC Contig of the Human CC Chemokine Genes Clustered On Chromosome 17q11.2." Genomics, vol. 34, no. 2, 1996, pp. 236-40.
Naruse K, Ueno M, Satoh T, et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996;34(2):236-40.
Naruse, K., Ueno, M., Satoh, T., Nomiyama, H., Tei, H., Takeda, M., Ledbetter, D. H., Coillie, E. V., Opdenakker, G., Gunge, N., Sakaki, Y., Iio, M., & Miura, R. (1996). A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 34(2), 236-40.
Naruse K, et al. A YAC Contig of the Human CC Chemokine Genes Clustered On Chromosome 17q11.2. Genomics. 1996 Jun 1;34(2):236-40. PubMed PMID: 8661057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. AU - Naruse,K, AU - Ueno,M, AU - Satoh,T, AU - Nomiyama,H, AU - Tei,H, AU - Takeda,M, AU - Ledbetter,D H, AU - Coillie,E V, AU - Opdenakker,G, AU - Gunge,N, AU - Sakaki,Y, AU - Iio,M, AU - Miura,R, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 236 EP - 40 JF - Genomics JO - Genomics VL - 34 IS - 2 N2 - CC chemokines are cytokines that attract and activate leukocytes. The human genes for the CC chemokines are clustered on chromosome 17. To elucidate the genomic organization of the CC chemokine genes, we constructed a YAC contig comprising 34 clones. The contig was shown to contain all 10 CC chemokine genes reported so far, except for one gene whose nucleotide sequence is not available. The contig also contains 4 CC chemokine-like genes, which were deposited in GenBank as ESTs and are here referred to as NCC-1, NCC-2, NCC-3, and NCC-4. Within the contig, the CC chemokine genes were localized in two regions. In addition, the CC chemokine genes were more precisely mapped on chromosome 17q11.2 using a somatic cell hybrid cell DNA panel containing various portions of human chromosome 17. Interestingly, a reciprocal translocation t(Y;17) breakpoint, contained in the hybrid cell line Y1741, lay between the two chromosome 17 chemokine gene regions covered by our YAC contig. From these results, the order and the orientation of CC chemokine genes on chromosome 17 were determined as follows: centromere-neurofibromatosis 1-(MCP-3, MCP-1, NCC-1, I-309)-Y1741 breakpoint-RANTES-(LD78gamma, AT744.2, LD78beta)-(NCC-3, NCC-2, AT744.1, LD78alpha)-NCC-4-retinoic acid receptor alpha- telomere. SN - 0888-7543 UR - https://www.unboundmedicine.com/medline/citation/8661057/A_YAC_contig_of_the_human_CC_chemokine_genes_clustered_on_chromosome_17q11_2_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0888-7543(96)90274-8 DB - PRIME DP - Unbound Medicine ER -