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A prospective study of urinary oestrogen excretion and breast cancer risk.

Abstract

To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects were diagnosed with breast cancer subsequent to urine collection. Among women who were premenopausal at the time of urine collection, cases excreted less oestrogen than controls; the odds ratios (95% CI) for breast cancer in the middle and upper thirds of the distribution of oestrogen excretion, in comparison with the lower third (reference group, assigned odds ratio = 1.0), were 0.5(0.2-1.2) and 0.4(0.2-1.1) respectively for oestrone, 0.8(0.4-1.8 and 0.4(0.2-1.1) for oestradiol, 0.7(0.3-1.6) and 0.7(0.3-1.6) for oestriol and 0.9(0.4-2.0) and 0.5(0.2-1.3) for total oestrogens. Among women who were post-menopausal at the time of urine collection, the trend was in the opposite direction, with an increase in risk associated with increased oestrogen excretion; the odds ratios were 0.9(0.3-2.2) and 1.1(0.5-2.8) for oestrone, 0.8(0.3-2.3) and 1.9(0.8-4.6) for oestradiol, 1.5(0.6-3.9) and 1.8(0.7-4.6) for oestriol and 0.9(0.4-2.6) and 1.9(0.7-4.7) for total oestrogens. The trends of increasing risk with increasing oestrogen excretion among post-menopausal women were statistically significant for oestradiol (P = 0.022) and for total oestrogens (P = 0.016). We conclude that high levels of endogenous oestrogens in post-menopausal women are associated with increased breast cancer risk, but that the relationship of oestrogens in premenopausal women with risk is unclear.

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  • Authors+Show Affiliations

    ,

    Imperial Cancer Research Fund, Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, UK.

    , , , , , , ,

    Source

    British journal of cancer 73:12 1996 Jun pg 1615-9

    MeSH

    Adult
    Breast Neoplasms
    Case-Control Studies
    Estradiol
    Estriol
    Estrogens
    Estrone
    Female
    Humans
    Middle Aged
    Postmenopause
    Premenopause
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    8664140

    Citation

    Key, T J., et al. "A Prospective Study of Urinary Oestrogen Excretion and Breast Cancer Risk." British Journal of Cancer, vol. 73, no. 12, 1996, pp. 1615-9.
    Key TJ, Wang DY, Brown JB, et al. A prospective study of urinary oestrogen excretion and breast cancer risk. Br J Cancer. 1996;73(12):1615-9.
    Key, T. J., Wang, D. Y., Brown, J. B., Hermon, C., Allen, D. S., Moore, J. W., ... Pike, M. C. (1996). A prospective study of urinary oestrogen excretion and breast cancer risk. British Journal of Cancer, 73(12), pp. 1615-9.
    Key TJ, et al. A Prospective Study of Urinary Oestrogen Excretion and Breast Cancer Risk. Br J Cancer. 1996;73(12):1615-9. PubMed PMID: 8664140.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of urinary oestrogen excretion and breast cancer risk. AU - Key,T J, AU - Wang,D Y, AU - Brown,J B, AU - Hermon,C, AU - Allen,D S, AU - Moore,J W, AU - Bulbrook,R D, AU - Fentiman,I S, AU - Pike,M C, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 1615 EP - 9 JF - British journal of cancer JO - Br. J. Cancer VL - 73 IS - 12 N2 - To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects were diagnosed with breast cancer subsequent to urine collection. Among women who were premenopausal at the time of urine collection, cases excreted less oestrogen than controls; the odds ratios (95% CI) for breast cancer in the middle and upper thirds of the distribution of oestrogen excretion, in comparison with the lower third (reference group, assigned odds ratio = 1.0), were 0.5(0.2-1.2) and 0.4(0.2-1.1) respectively for oestrone, 0.8(0.4-1.8 and 0.4(0.2-1.1) for oestradiol, 0.7(0.3-1.6) and 0.7(0.3-1.6) for oestriol and 0.9(0.4-2.0) and 0.5(0.2-1.3) for total oestrogens. Among women who were post-menopausal at the time of urine collection, the trend was in the opposite direction, with an increase in risk associated with increased oestrogen excretion; the odds ratios were 0.9(0.3-2.2) and 1.1(0.5-2.8) for oestrone, 0.8(0.3-2.3) and 1.9(0.8-4.6) for oestradiol, 1.5(0.6-3.9) and 1.8(0.7-4.6) for oestriol and 0.9(0.4-2.6) and 1.9(0.7-4.7) for total oestrogens. The trends of increasing risk with increasing oestrogen excretion among post-menopausal women were statistically significant for oestradiol (P = 0.022) and for total oestrogens (P = 0.016). We conclude that high levels of endogenous oestrogens in post-menopausal women are associated with increased breast cancer risk, but that the relationship of oestrogens in premenopausal women with risk is unclear. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/8664140/A_prospective_study_of_urinary_oestrogen_excretion_and_breast_cancer_risk_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8664140/ DB - PRIME DP - Unbound Medicine ER -