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Physical activity, waist-to-hip ratio, and other risk factors for ovarian cancer: a follow-up study of older women.

Abstract

We investigated the association of epithelial ovarian cancer with physical activity, waist-to-hip ratio, reproductive factors, and family history of cancer in a prospective cohort study of 31,396 postmenopausal women. Ninety-seven women developed incident epithelial ovarian cancer over 7 years. The number of livebirths was associated with lower risk (multivariate-adjusted relative risks for 1-2, 3-4, and > 4 livebirths compared with nulliparity were 0.64, 0.47, and 0.43, respectively). A family history of ovarian cancer in a first-degree relative was associated with a 2.5 times greater risk (95% confidence interval = 0.90-6.7). Multivariate-adjusted relative risks for the upper three quartiles of waist-to-hip ratio compared with the lowest quartile were 2.0, 1.6, and 2.3, respectively. Women with "moderate" and "high" levels of physical activity compared with those with "low" physical activity had relative risks of 1.4 and 2.1, respectively. Positive associations of physical activity and waist-to-hip ratio with ovarian cancer seem inconsistent with existing theories of ovarian cancer pathogenesis.

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  • Authors+Show Affiliations

    ,

    School of Public Health, University of Minnesota, MN 55454-1015, USA.

    , ,

    Source

    Epidemiology (Cambridge, Mass.) 7:1 1996 Jan pg 38-45

    MeSH

    Aged
    Body Constitution
    Carcinoma
    Cohort Studies
    Exercise
    Family Health
    Female
    Follow-Up Studies
    Humans
    Incidence
    Iowa
    Middle Aged
    Multivariate Analysis
    Obesity
    Odds Ratio
    Ovarian Neoplasms
    Ovulation
    Proportional Hazards Models
    Prospective Studies
    Random Allocation
    Reproductive History
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8664399

    Citation

    Mink, P J., et al. "Physical Activity, Waist-to-hip Ratio, and Other Risk Factors for Ovarian Cancer: a Follow-up Study of Older Women." Epidemiology (Cambridge, Mass.), vol. 7, no. 1, 1996, pp. 38-45.
    Mink PJ, Folsom AR, Sellers TA, et al. Physical activity, waist-to-hip ratio, and other risk factors for ovarian cancer: a follow-up study of older women. Epidemiology. 1996;7(1):38-45.
    Mink, P. J., Folsom, A. R., Sellers, T. A., & Kushi, L. H. (1996). Physical activity, waist-to-hip ratio, and other risk factors for ovarian cancer: a follow-up study of older women. Epidemiology (Cambridge, Mass.), 7(1), pp. 38-45.
    Mink PJ, et al. Physical Activity, Waist-to-hip Ratio, and Other Risk Factors for Ovarian Cancer: a Follow-up Study of Older Women. Epidemiology. 1996;7(1):38-45. PubMed PMID: 8664399.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity, waist-to-hip ratio, and other risk factors for ovarian cancer: a follow-up study of older women. AU - Mink,P J, AU - Folsom,A R, AU - Sellers,T A, AU - Kushi,L H, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 38 EP - 45 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 7 IS - 1 N2 - We investigated the association of epithelial ovarian cancer with physical activity, waist-to-hip ratio, reproductive factors, and family history of cancer in a prospective cohort study of 31,396 postmenopausal women. Ninety-seven women developed incident epithelial ovarian cancer over 7 years. The number of livebirths was associated with lower risk (multivariate-adjusted relative risks for 1-2, 3-4, and > 4 livebirths compared with nulliparity were 0.64, 0.47, and 0.43, respectively). A family history of ovarian cancer in a first-degree relative was associated with a 2.5 times greater risk (95% confidence interval = 0.90-6.7). Multivariate-adjusted relative risks for the upper three quartiles of waist-to-hip ratio compared with the lowest quartile were 2.0, 1.6, and 2.3, respectively. Women with "moderate" and "high" levels of physical activity compared with those with "low" physical activity had relative risks of 1.4 and 2.1, respectively. Positive associations of physical activity and waist-to-hip ratio with ovarian cancer seem inconsistent with existing theories of ovarian cancer pathogenesis. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/8664399/Physical_activity_waist_to_hip_ratio_and_other_risk_factors_for_ovarian_cancer:_a_follow_up_study_of_older_women_ L2 - http://Insights.ovid.com/pubmed?pmid=8664399 DB - PRIME DP - Unbound Medicine ER -