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Neuroprotection by melatonin from kainate-induced excitotoxicity in rats.
FASEB J. 1996 Jun; 10(8):891-6.FJ

Abstract

In this study, we injected 10 mg/kg kainate i.p. into rats. This resulted in a brain injury, which we quantified in the hippocampus, the amygdala, and the pyriform cortex. Neuronal damage was preceded by a set of typical behavioral signs and by biochemical changes (noradrenaline decrease and 5-hydroxyindoleacetic acid increase) in the affected brain areas. Melatonin (2.5 mg/kg) was injected i.p. four times: 20 min before kainate, immediately after, and 1 and 2 h after the kainate. The cumulative dose of 10 mg/kg melatonin prevented kainate-induced neuronal death as well as behavioral and biochemical disturbances. A possible mechanism of melatonin-provided neuroprotection lies in its antioxidant action. Our results suggest that melatonin holds potential for the treatment of pathologies such as epilepsy-associated brain damage, stroke, and brain trauma.

Authors+Show Affiliations

Giusti P
Department of Pharmacology, University of Padua, Italy.
Lipartiti M
No affiliation info available
Franceschini D
No affiliation info available
Schiavo N
No affiliation info available
Floreani M
No affiliation info available
Manev H
No affiliation info available

MeSH

AnimalsAntioxidantsBehavior, AnimalBrainKainic AcidMaleMelatoninRatsRats, Wistar

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8666166

Citation

Giusti, P, et al. "Neuroprotection By Melatonin From Kainate-induced Excitotoxicity in Rats." FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 10, no. 8, 1996, pp. 891-6.
Giusti P, Lipartiti M, Franceschini D, et al. Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. FASEB J. 1996;10(8):891-6.
Giusti, P., Lipartiti, M., Franceschini, D., Schiavo, N., Floreani, M., & Manev, H. (1996). Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 10(8), 891-6.
Giusti P, et al. Neuroprotection By Melatonin From Kainate-induced Excitotoxicity in Rats. FASEB J. 1996;10(8):891-6. PubMed PMID: 8666166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. AU - Giusti,P, AU - Lipartiti,M, AU - Franceschini,D, AU - Schiavo,N, AU - Floreani,M, AU - Manev,H, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 891 EP - 6 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology JO - FASEB J VL - 10 IS - 8 N2 - In this study, we injected 10 mg/kg kainate i.p. into rats. This resulted in a brain injury, which we quantified in the hippocampus, the amygdala, and the pyriform cortex. Neuronal damage was preceded by a set of typical behavioral signs and by biochemical changes (noradrenaline decrease and 5-hydroxyindoleacetic acid increase) in the affected brain areas. Melatonin (2.5 mg/kg) was injected i.p. four times: 20 min before kainate, immediately after, and 1 and 2 h after the kainate. The cumulative dose of 10 mg/kg melatonin prevented kainate-induced neuronal death as well as behavioral and biochemical disturbances. A possible mechanism of melatonin-provided neuroprotection lies in its antioxidant action. Our results suggest that melatonin holds potential for the treatment of pathologies such as epilepsy-associated brain damage, stroke, and brain trauma. SN - 0892-6638 UR - https://www.unboundmedicine.com/medline/citation/8666166/Neuroprotection_by_melatonin_from_kainate_induced_excitotoxicity_in_rats_ L2 - https://doi.org/10.1096/fasebj.10.8.8666166 DB - PRIME DP - Unbound Medicine ER -