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Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail.
Am J Vet Res. 1996 Mar; 57(3):342-5.AJ

Abstract

OBJECTIVE

To investigate the involvement of (n-6) essential fatty acids, such as linoleic acid [18:2(n-6)] or gamma-linolenic acid [18:3(n-6)], and of prostaglandins on liver lipid accumulation in Japanese quail.

DESIGN

Effects of graded amounts of aspirin, which inhibits prostaglandin synthesis, on liver weight were determined in experiment 1. Experiment 2 was designed to clarify the effect of dietary essential fatty acid sources and inhibition of prostaglandin synthesis on the liver fat and fatty acid profile.

ANIMALS

Female Japanese quail.

PROCEDURE

In experiment 1, from 1 to 3 weeks of age, birds were fed ad libitum the essential fatty acids-free or linoleic acid-adequate (2%) diets with graded amounts of aspirin (0, 0.1, 0.2, and 0.4%). In experiment 2, from 1 to 4 weeks of age, birds were fed the same amount of essential fatty acids-free, linoleic acid-adequate, or gamma-linolenic acid (0.4%) diets with (0.2%) or without aspirin.

RESULTS

In experiment 1, in groups given the essential fatty acids-free diet, liver weight increased with an increase in dietary aspirin concentration. In experiment 2, gamma-linolenic acid completely prevented liver triacylglycerol and cholesterol accumulation induced by the essential fatty acids-free diet. Aspirin treatment significantly lowered plasma prostaglandin F2 alpha concentration, but did not affect liver lipid concentrations. In groups fed the essential fatty acids-free diets, however, aspirin treatment increased liver weight and liver triacylglycerol concentration by 20 and 40%, respectively.

CONCLUSIONS

gamma-Linolenic acid or its metabolites, but not linoleic acid itself, are important factors in reducing fatty liver in Japanese quail with the essential fatty acids-deficient condition.

Authors+Show Affiliations

Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8669766

Citation

Murai, A, et al. "Involvement of (n-6) Essential Fatty Acids and Prostaglandins in Liver Lipid Accumulation in Japanese Quail." American Journal of Veterinary Research, vol. 57, no. 3, 1996, pp. 342-5.
Murai A, Furuse M, Okumura J. Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail. Am J Vet Res. 1996;57(3):342-5.
Murai, A., Furuse, M., & Okumura, J. (1996). Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail. American Journal of Veterinary Research, 57(3), 342-5.
Murai A, Furuse M, Okumura J. Involvement of (n-6) Essential Fatty Acids and Prostaglandins in Liver Lipid Accumulation in Japanese Quail. Am J Vet Res. 1996;57(3):342-5. PubMed PMID: 8669766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail. AU - Murai,A, AU - Furuse,M, AU - Okumura,J, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 342 EP - 5 JF - American journal of veterinary research JO - Am J Vet Res VL - 57 IS - 3 N2 - OBJECTIVE: To investigate the involvement of (n-6) essential fatty acids, such as linoleic acid [18:2(n-6)] or gamma-linolenic acid [18:3(n-6)], and of prostaglandins on liver lipid accumulation in Japanese quail. DESIGN: Effects of graded amounts of aspirin, which inhibits prostaglandin synthesis, on liver weight were determined in experiment 1. Experiment 2 was designed to clarify the effect of dietary essential fatty acid sources and inhibition of prostaglandin synthesis on the liver fat and fatty acid profile. ANIMALS: Female Japanese quail. PROCEDURE: In experiment 1, from 1 to 3 weeks of age, birds were fed ad libitum the essential fatty acids-free or linoleic acid-adequate (2%) diets with graded amounts of aspirin (0, 0.1, 0.2, and 0.4%). In experiment 2, from 1 to 4 weeks of age, birds were fed the same amount of essential fatty acids-free, linoleic acid-adequate, or gamma-linolenic acid (0.4%) diets with (0.2%) or without aspirin. RESULTS: In experiment 1, in groups given the essential fatty acids-free diet, liver weight increased with an increase in dietary aspirin concentration. In experiment 2, gamma-linolenic acid completely prevented liver triacylglycerol and cholesterol accumulation induced by the essential fatty acids-free diet. Aspirin treatment significantly lowered plasma prostaglandin F2 alpha concentration, but did not affect liver lipid concentrations. In groups fed the essential fatty acids-free diets, however, aspirin treatment increased liver weight and liver triacylglycerol concentration by 20 and 40%, respectively. CONCLUSIONS: gamma-Linolenic acid or its metabolites, but not linoleic acid itself, are important factors in reducing fatty liver in Japanese quail with the essential fatty acids-deficient condition. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/8669766/Involvement_of__n_6__essential_fatty_acids_and_prostaglandins_in_liver_lipid_accumulation_in_Japanese_quail_ L2 - https://medlineplus.gov/dietaryfats.html DB - PRIME DP - Unbound Medicine ER -