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Dermal papilla cells derived from beard hair follicles secrete more stem cell factor (SCF) in culture than scalp cells or dermal fibroblasts.
Biochem Biophys Res Commun. 1996 May 15; 222(2):401-5.BB

Abstract

As stem cell factor (SCF) and its receptor, c-kit, are involved in hair pigmentation, SCF is probably produced in the skin, possibly by the regulatory follicular dermal papilla. Since androgens often alter the type and color of hair, probably via the dermal papilla, they may regulate its SCF production. SCF produced by beard and non-balding scalp dermal papilla cells in the presence, or absence, of 10nM testosterone was assayed by ELISA. After 24 h, beard cells produced significantly (p = 0.001) more SCF than scalp cells, while beard and scalp fibroblasts secreted significantly (p = 0.04) less SCF. Testosterone in vitro had no effect on SCF secretion. These results support the hypotheses that the dermal papilla is a local source of SCF in hair follicles and that androgens would alter SCF production only at specific points of the hair cycle.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Bradford, United Kingdom.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8670217

Citation

Hibberts, N A., et al. "Dermal Papilla Cells Derived From Beard Hair Follicles Secrete More Stem Cell Factor (SCF) in Culture Than Scalp Cells or Dermal Fibroblasts." Biochemical and Biophysical Research Communications, vol. 222, no. 2, 1996, pp. 401-5.
Hibberts NA, Messenger AG, Randall VA. Dermal papilla cells derived from beard hair follicles secrete more stem cell factor (SCF) in culture than scalp cells or dermal fibroblasts. Biochem Biophys Res Commun. 1996;222(2):401-5.
Hibberts, N. A., Messenger, A. G., & Randall, V. A. (1996). Dermal papilla cells derived from beard hair follicles secrete more stem cell factor (SCF) in culture than scalp cells or dermal fibroblasts. Biochemical and Biophysical Research Communications, 222(2), 401-5.
Hibberts NA, Messenger AG, Randall VA. Dermal Papilla Cells Derived From Beard Hair Follicles Secrete More Stem Cell Factor (SCF) in Culture Than Scalp Cells or Dermal Fibroblasts. Biochem Biophys Res Commun. 1996 May 15;222(2):401-5. PubMed PMID: 8670217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dermal papilla cells derived from beard hair follicles secrete more stem cell factor (SCF) in culture than scalp cells or dermal fibroblasts. AU - Hibberts,N A, AU - Messenger,A G, AU - Randall,V A, PY - 1996/5/15/pubmed PY - 1996/5/15/medline PY - 1996/5/15/entrez SP - 401 EP - 5 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 222 IS - 2 N2 - As stem cell factor (SCF) and its receptor, c-kit, are involved in hair pigmentation, SCF is probably produced in the skin, possibly by the regulatory follicular dermal papilla. Since androgens often alter the type and color of hair, probably via the dermal papilla, they may regulate its SCF production. SCF produced by beard and non-balding scalp dermal papilla cells in the presence, or absence, of 10nM testosterone was assayed by ELISA. After 24 h, beard cells produced significantly (p = 0.001) more SCF than scalp cells, while beard and scalp fibroblasts secreted significantly (p = 0.04) less SCF. Testosterone in vitro had no effect on SCF secretion. These results support the hypotheses that the dermal papilla is a local source of SCF in hair follicles and that androgens would alter SCF production only at specific points of the hair cycle. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/8670217/Dermal_papilla_cells_derived_from_beard_hair_follicles_secrete_more_stem_cell_factor__SCF__in_culture_than_scalp_cells_or_dermal_fibroblasts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(96)90756-1 DB - PRIME DP - Unbound Medicine ER -