Tags

Type your tag names separated by a space and hit enter

Serum tumor markers and cyst fluid analysis are useful for the diagnosis of pancreatic cystic tumors.
Cancer. 1996 Jul 15; 78(2):237-43.C

Abstract

BACKGROUND

This study was performed to evaluate the utility of serum and cyst fluid analysis for enzymes (amylase and lipase) and tumor markers (carcinoembryonic antigen, CA 19-9, CA 125, and CA 72-4) in the differential diagnosis of cystic pancreatic lesions.

METHODS

Serum and cyst fluid were obtained from 48 patients with pancreatic cysts (21 pseudocysts, 14 mucinous cystic neoplasms, 6 ductal carcinomas, and 7 serous cystadenomas), observed between 1989 and 1994.

RESULTS

Serum CA 19-9 levels were significantly higher in ductal carcinomas (all > 100 U/mL) and mucinous cystic neoplasms (P < 0.05). CA 72-4 cyst fluid levels were significantly higher in mucinous cystic tumors (P < 0.005), with 95% specificity and 80% sensitivity in detecting mucinous or malignant cysts. A combined assay of serum CA 19-9 and cyst fluid CA 72-4 correctly identified 19 of 20 (pre-) malignant lesions (95%), with only 1 false-positive result (3.6%). Cytology showed a sensitivity of 48% and specificity of 100%.

CONCLUSIONS

Any pancreatic cyst with high serum CA 19-9 values, positive cytology, or high CA 72-4 in the fluid should be considered for resection.

Authors+Show Affiliations

Department of Surgery, University of Padua, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8673998

Citation

Sperti, C, et al. "Serum Tumor Markers and Cyst Fluid Analysis Are Useful for the Diagnosis of Pancreatic Cystic Tumors." Cancer, vol. 78, no. 2, 1996, pp. 237-43.
Sperti C, Pasquali C, Guolo P, et al. Serum tumor markers and cyst fluid analysis are useful for the diagnosis of pancreatic cystic tumors. Cancer. 1996;78(2):237-43.
Sperti, C., Pasquali, C., Guolo, P., Polverosi, R., Liessi, G., & Pedrazzoli, S. (1996). Serum tumor markers and cyst fluid analysis are useful for the diagnosis of pancreatic cystic tumors. Cancer, 78(2), 237-43.
Sperti C, et al. Serum Tumor Markers and Cyst Fluid Analysis Are Useful for the Diagnosis of Pancreatic Cystic Tumors. Cancer. 1996 Jul 15;78(2):237-43. PubMed PMID: 8673998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum tumor markers and cyst fluid analysis are useful for the diagnosis of pancreatic cystic tumors. AU - Sperti,C, AU - Pasquali,C, AU - Guolo,P, AU - Polverosi,R, AU - Liessi,G, AU - Pedrazzoli,S, PY - 1996/7/15/pubmed PY - 2000/6/20/medline PY - 1996/7/15/entrez SP - 237 EP - 43 JF - Cancer JO - Cancer VL - 78 IS - 2 N2 - BACKGROUND: This study was performed to evaluate the utility of serum and cyst fluid analysis for enzymes (amylase and lipase) and tumor markers (carcinoembryonic antigen, CA 19-9, CA 125, and CA 72-4) in the differential diagnosis of cystic pancreatic lesions. METHODS: Serum and cyst fluid were obtained from 48 patients with pancreatic cysts (21 pseudocysts, 14 mucinous cystic neoplasms, 6 ductal carcinomas, and 7 serous cystadenomas), observed between 1989 and 1994. RESULTS: Serum CA 19-9 levels were significantly higher in ductal carcinomas (all > 100 U/mL) and mucinous cystic neoplasms (P < 0.05). CA 72-4 cyst fluid levels were significantly higher in mucinous cystic tumors (P < 0.005), with 95% specificity and 80% sensitivity in detecting mucinous or malignant cysts. A combined assay of serum CA 19-9 and cyst fluid CA 72-4 correctly identified 19 of 20 (pre-) malignant lesions (95%), with only 1 false-positive result (3.6%). Cytology showed a sensitivity of 48% and specificity of 100%. CONCLUSIONS: Any pancreatic cyst with high serum CA 19-9 values, positive cytology, or high CA 72-4 in the fluid should be considered for resection. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/8673998/Serum_tumor_markers_and_cyst_fluid_analysis_are_useful_for_the_diagnosis_of_pancreatic_cystic_tumors_ DB - PRIME DP - Unbound Medicine ER -