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Celiac disease and pregnancy outcome.
Am J Gastroenterol 1996; 91(4):718-22AJ

Abstract

OBJECTIVES

This study investigated the effect of gluten-free diet on pregnancy outcome and lactation in 125 women affected with celiac disease.

METHODS

The study has been designed as a case-control study and a before-after study.

RESULTS

In the case-control study, comparison of 94 untreated with 31 treated celiac women indicated that the relative risk of abortion was 8.90 times higher (95% confidence limits: 1.19/66.3), the relative risk of low birth weight baby was 5.84 times higher (90% confidence limits: 1.07/31.9), and duration of breast feeding was 2.54 times shorter (p < 0.001) in untreated mothers. Abortion, low birth weight of baby, and duration of breast feeding did not significantly relate to the severity of celiac disease among untreated women. In the before-after study, 12 pregnant celiac women in either treated or untreated condition were compared. Results indicated that the gluten-free diet reduced the relative risk of abortion by 9.18 times (95% confidence limits: 1.05/79.9), reduced the number of low birth weight babies from 29.4% down to zero (p < 0.05), and increased duration of breast feeding 2.38 times (p < 0.10). Both case-control and before-after studies indicated that threatened abortion and premature delivery did not significantly relate to treatment of celiac disease.

CONCLUSIONS

The high incidence of abortion, of low birth weight babies, and of short breast-feeding periods is effectively corrected by gluten-free diet in women with celiac disease.

Authors+Show Affiliations

Gastroenterology, Medical School, Naples University "Federico II," Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8677936

Citation

Ciacci, C, et al. "Celiac Disease and Pregnancy Outcome." The American Journal of Gastroenterology, vol. 91, no. 4, 1996, pp. 718-22.
Ciacci C, Cirillo M, Auriemma G, et al. Celiac disease and pregnancy outcome. Am J Gastroenterol. 1996;91(4):718-22.
Ciacci, C., Cirillo, M., Auriemma, G., Di Dato, G., Sabbatini, F., & Mazzacca, G. (1996). Celiac disease and pregnancy outcome. The American Journal of Gastroenterology, 91(4), pp. 718-22.
Ciacci C, et al. Celiac Disease and Pregnancy Outcome. Am J Gastroenterol. 1996;91(4):718-22. PubMed PMID: 8677936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Celiac disease and pregnancy outcome. AU - Ciacci,C, AU - Cirillo,M, AU - Auriemma,G, AU - Di Dato,G, AU - Sabbatini,F, AU - Mazzacca,G, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 718 EP - 22 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 91 IS - 4 N2 - OBJECTIVES: This study investigated the effect of gluten-free diet on pregnancy outcome and lactation in 125 women affected with celiac disease. METHODS: The study has been designed as a case-control study and a before-after study. RESULTS: In the case-control study, comparison of 94 untreated with 31 treated celiac women indicated that the relative risk of abortion was 8.90 times higher (95% confidence limits: 1.19/66.3), the relative risk of low birth weight baby was 5.84 times higher (90% confidence limits: 1.07/31.9), and duration of breast feeding was 2.54 times shorter (p < 0.001) in untreated mothers. Abortion, low birth weight of baby, and duration of breast feeding did not significantly relate to the severity of celiac disease among untreated women. In the before-after study, 12 pregnant celiac women in either treated or untreated condition were compared. Results indicated that the gluten-free diet reduced the relative risk of abortion by 9.18 times (95% confidence limits: 1.05/79.9), reduced the number of low birth weight babies from 29.4% down to zero (p < 0.05), and increased duration of breast feeding 2.38 times (p < 0.10). Both case-control and before-after studies indicated that threatened abortion and premature delivery did not significantly relate to treatment of celiac disease. CONCLUSIONS: The high incidence of abortion, of low birth weight babies, and of short breast-feeding periods is effectively corrected by gluten-free diet in women with celiac disease. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/8677936/Celiac_disease_and_pregnancy_outcome_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -