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Progressive osseous heteroplasia.
Arch Dermatol 1996; 132(7):787-91AD

Abstract

BACKGROUND

Primary heterotopic ossification beginning in childhood is quite rare but occurs in several well-described conditions, such as Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva, and platelike osteoma cutis. Recently, a new disorder called progressive osseous heteroplasia (POH) has been described in the orthopedic literature. Primary cutaneous calcification and ossification beginning in infancy are presenting signs of this progressive and potentially debilitating disorder.

OBSERVATIONS

We describe 2 children with POH who were recently seen at Children's Hospital of Wisconsin. Both children were female and developed cutaneous calcification and ossification within the first 6 months of life. Both girls had progression of the lesions to involve ossification of the deeper tissues. No abnormalities in calcium, phosphorus, vitamin D, or parathyroid hormone levels were identified in these patients. No associated anomalies were detected. Biopsy results from the lesions showed calcinosis cutis superficially, with both endochondral and intramembranous bone formation in the deeper tissues.

CONCLUSIONS

Progressive osseous heteroplasia must now be included in the differential diagnosis of primary cutaneous ossification beginning in childhood. Because the first clinical manifestations of POH appear in the skin. It is important for dermatologists to be aware of this newly described condition.

Authors+Show Affiliations

Department of Dermatology, Medical College of Wisconsin, Milwaukee, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8678571

Citation

Miller, E S., et al. "Progressive Osseous Heteroplasia." Archives of Dermatology, vol. 132, no. 7, 1996, pp. 787-91.
Miller ES, Esterly NB, Fairley JA. Progressive osseous heteroplasia. Arch Dermatol. 1996;132(7):787-91.
Miller, E. S., Esterly, N. B., & Fairley, J. A. (1996). Progressive osseous heteroplasia. Archives of Dermatology, 132(7), pp. 787-91.
Miller ES, Esterly NB, Fairley JA. Progressive Osseous Heteroplasia. Arch Dermatol. 1996;132(7):787-91. PubMed PMID: 8678571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive osseous heteroplasia. AU - Miller,E S, AU - Esterly,N B, AU - Fairley,J A, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 787 EP - 91 JF - Archives of dermatology JO - Arch Dermatol VL - 132 IS - 7 N2 - BACKGROUND: Primary heterotopic ossification beginning in childhood is quite rare but occurs in several well-described conditions, such as Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva, and platelike osteoma cutis. Recently, a new disorder called progressive osseous heteroplasia (POH) has been described in the orthopedic literature. Primary cutaneous calcification and ossification beginning in infancy are presenting signs of this progressive and potentially debilitating disorder. OBSERVATIONS: We describe 2 children with POH who were recently seen at Children's Hospital of Wisconsin. Both children were female and developed cutaneous calcification and ossification within the first 6 months of life. Both girls had progression of the lesions to involve ossification of the deeper tissues. No abnormalities in calcium, phosphorus, vitamin D, or parathyroid hormone levels were identified in these patients. No associated anomalies were detected. Biopsy results from the lesions showed calcinosis cutis superficially, with both endochondral and intramembranous bone formation in the deeper tissues. CONCLUSIONS: Progressive osseous heteroplasia must now be included in the differential diagnosis of primary cutaneous ossification beginning in childhood. Because the first clinical manifestations of POH appear in the skin. It is important for dermatologists to be aware of this newly described condition. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/8678571/Progressive_osseous_heteroplasia_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/132/pg/787 DB - PRIME DP - Unbound Medicine ER -