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Hepatic blood flow after acute biliary obstruction and drainage in conscious dogs.
Hepatogastroenterology. 1996 Jan-Feb; 43(7):235-40.H

Abstract

BACKGROUND AIMS

Obstructive jaundice is a factor which effects hepatic blood flow and the relative contribution of the hepatic arterial flow and portal venous flow. In this study, and were measured in conscious dogs and the influence of biliary obstruction and drainage was investigated.

MATERIAL AND METHODS

Hepatic arterial flow (HAF) and portal venous flow (PVF) after biliary obstruction and subsequent drainage were continuously measured in conscious dogs using implantable transit time ultrasonic flow-meters.

RESULTS

After biliary obstruction hepatic arterial flow rapidly increased compared to the pre-obstructed values(p < 0.01), while portal venous flow was significantly decreased (p < 0.01). Total hepatic blood flow was initially increased (p < 0.01) until 2 hours after obstruction. It then decreased gradually. After 2 weeks, it was less than the pre-obstructed values, but this was not significant. Biliary drainage was performed after 2 weeks. Hepatic arterial flow subsequently decreased (p < 0.01) and portal venous flow increased (p < 0.05). Blood flow did not change.

CONCLUSION

Biliary obstruction resulted in significant changes in liver circulation. Biliary drainage facilitated recovery from these changes.

Authors+Show Affiliations

Kanda H
First Department of Surgery, Nagoya University School of Medicine.
Nimura Y
No affiliation info available
Yasui A
No affiliation info available
Uematsu T
No affiliation info available
Kamiya S
No affiliation info available
Machiki Y
No affiliation info available
Kitagawa Y
No affiliation info available
Shionoya S
No affiliation info available

MeSH

AnimalsBlood Flow VelocityCholestasisDogsDrainageFemaleHepatic ArteryLiver CirculationMalePortal Vein

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8682470

Citation

Kanda, H, et al. "Hepatic Blood Flow After Acute Biliary Obstruction and Drainage in Conscious Dogs." Hepato-gastroenterology, vol. 43, no. 7, 1996, pp. 235-40.
Kanda H, Nimura Y, Yasui A, et al. Hepatic blood flow after acute biliary obstruction and drainage in conscious dogs. Hepatogastroenterology. 1996;43(7):235-40.
Kanda, H., Nimura, Y., Yasui, A., Uematsu, T., Kamiya, S., Machiki, Y., Kitagawa, Y., & Shionoya, S. (1996). Hepatic blood flow after acute biliary obstruction and drainage in conscious dogs. Hepato-gastroenterology, 43(7), 235-40.
Kanda H, et al. Hepatic Blood Flow After Acute Biliary Obstruction and Drainage in Conscious Dogs. Hepatogastroenterology. 1996 Jan-Feb;43(7):235-40. PubMed PMID: 8682470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic blood flow after acute biliary obstruction and drainage in conscious dogs. AU - Kanda,H, AU - Nimura,Y, AU - Yasui,A, AU - Uematsu,T, AU - Kamiya,S, AU - Machiki,Y, AU - Kitagawa,Y, AU - Shionoya,S, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 235 EP - 40 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 43 IS - 7 N2 - BACKGROUND AIMS: Obstructive jaundice is a factor which effects hepatic blood flow and the relative contribution of the hepatic arterial flow and portal venous flow. In this study, and were measured in conscious dogs and the influence of biliary obstruction and drainage was investigated. MATERIAL AND METHODS: Hepatic arterial flow (HAF) and portal venous flow (PVF) after biliary obstruction and subsequent drainage were continuously measured in conscious dogs using implantable transit time ultrasonic flow-meters. RESULTS: After biliary obstruction hepatic arterial flow rapidly increased compared to the pre-obstructed values(p < 0.01), while portal venous flow was significantly decreased (p < 0.01). Total hepatic blood flow was initially increased (p < 0.01) until 2 hours after obstruction. It then decreased gradually. After 2 weeks, it was less than the pre-obstructed values, but this was not significant. Biliary drainage was performed after 2 weeks. Hepatic arterial flow subsequently decreased (p < 0.01) and portal venous flow increased (p < 0.05). Blood flow did not change. CONCLUSION: Biliary obstruction resulted in significant changes in liver circulation. Biliary drainage facilitated recovery from these changes. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/8682470/Hepatic_blood_flow_after_acute_biliary_obstruction_and_drainage_in_conscious_dogs_ DB - PRIME DP - Unbound Medicine ER -