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[Use of molecular genetics in the early diagnosis of familial adenomatous polyposis].
Vnitr Lek. 1996 Mar; 42(3):188-90.VL

Abstract

Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary precancerous condition manifested by hundreds to thousands of polyps in the colon and rectum. Practically, with a 100% certainty, patients with FAP develop carcinoma of the colon or rectum. FAP is this the most dangerous sign of a precancerous condition. So far the only possibility of early diagnosis of this disease was rectoscopy or colonoscopy of risk subjects after annual intervals up to advanced age, After localization of the gene responsible for the development of FAP and discovery of its internal structure, possibilities for revealing FAP, decades before the first clinical symptoms appear, were disclosed.

Authors+Show Affiliations

Centrum lekárskej genetiky, Bratislava.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

slo

PubMed ID

8686208

Citation

Simko, J, and V Zajac. "[Use of Molecular Genetics in the Early Diagnosis of Familial Adenomatous Polyposis]." Vnitrni Lekarstvi, vol. 42, no. 3, 1996, pp. 188-90.
Simko J, Zajac V. [Use of molecular genetics in the early diagnosis of familial adenomatous polyposis]. Vnitr Lek. 1996;42(3):188-90.
Simko, J., & Zajac, V. (1996). [Use of molecular genetics in the early diagnosis of familial adenomatous polyposis]. Vnitrni Lekarstvi, 42(3), 188-90.
Simko J, Zajac V. [Use of Molecular Genetics in the Early Diagnosis of Familial Adenomatous Polyposis]. Vnitr Lek. 1996;42(3):188-90. PubMed PMID: 8686208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Use of molecular genetics in the early diagnosis of familial adenomatous polyposis]. AU - Simko,J, AU - Zajac,V, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 188 EP - 90 JF - Vnitrni lekarstvi JO - Vnitr Lek VL - 42 IS - 3 N2 - Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary precancerous condition manifested by hundreds to thousands of polyps in the colon and rectum. Practically, with a 100% certainty, patients with FAP develop carcinoma of the colon or rectum. FAP is this the most dangerous sign of a precancerous condition. So far the only possibility of early diagnosis of this disease was rectoscopy or colonoscopy of risk subjects after annual intervals up to advanced age, After localization of the gene responsible for the development of FAP and discovery of its internal structure, possibilities for revealing FAP, decades before the first clinical symptoms appear, were disclosed. SN - 0042-773X UR - https://www.unboundmedicine.com/medline/citation/8686208/[Use_of_molecular_genetics_in_the_early_diagnosis_of_familial_adenomatous_polyposis]_ L2 - http://www.diseaseinfosearch.org/result/2766 DB - PRIME DP - Unbound Medicine ER -
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