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Mortality following fractures in older women. The study of osteoporotic fractures.
Arch Intern Med. 1996 Jul 22; 156(14):1521-5.AI

Abstract

BACKGROUND

Most investigators have hypothesized that the increase in mortality following osteoporotic fractures reflects poor underlying health status in addition to the acute effects of the fracture.

METHODS

We observed 9704 ambulatory women aged 65 years or older enrolled in the Study of Osteoporotic Fractures. We obtained reports of fractures and deaths every 4 months and reviewed death certificates and hospital discharge summaries. Multivariable proportional hazards models were used to determine the association between fractures and age-adjusted mortality.

RESULTS

During a mean follow-up of 5.9 years, 1737 women had nonspine fractures, with a postfracture mortality rate of 3 per 100 woman-years, compared with 1.8 per 100 woman-years in those who did not have fractures (P < .001). After adjusting for other factors associated with mortality, women (n = 361) with fractures of the hip or pelvis had a 2.4-fold (95% confidence interval, 1.7-3.3) increase in mortality. However, only 9 (14%) of the 64 deaths that occurred after hip or pelvic fractures were caused or hastened by the fracture. By contrast, 11 (17%) of these deaths seemed to have been a result of chronic conditions that has contributed to the hip or pelvic fracture, and 44 (69%) of the deaths were not clearly related to the fracture.

CONCLUSIONS

Mortality is increased following several types of fractures in older women. Most of the increase following hip and pelvic fractures is due to underlying conditions and probably would not be affected by reductions in the incidence of these fractures.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, University of California-San Francisco, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8687260

Citation

Browner, W S., et al. "Mortality Following Fractures in Older Women. the Study of Osteoporotic Fractures." Archives of Internal Medicine, vol. 156, no. 14, 1996, pp. 1521-5.
Browner WS, Pressman AR, Nevitt MC, et al. Mortality following fractures in older women. The study of osteoporotic fractures. Arch Intern Med. 1996;156(14):1521-5.
Browner, W. S., Pressman, A. R., Nevitt, M. C., & Cummings, S. R. (1996). Mortality following fractures in older women. The study of osteoporotic fractures. Archives of Internal Medicine, 156(14), 1521-5.
Browner WS, et al. Mortality Following Fractures in Older Women. the Study of Osteoporotic Fractures. Arch Intern Med. 1996 Jul 22;156(14):1521-5. PubMed PMID: 8687260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mortality following fractures in older women. The study of osteoporotic fractures. AU - Browner,W S, AU - Pressman,A R, AU - Nevitt,M C, AU - Cummings,S R, PY - 1996/7/22/pubmed PY - 1996/7/22/medline PY - 1996/7/22/entrez SP - 1521 EP - 5 JF - Archives of internal medicine JO - Arch Intern Med VL - 156 IS - 14 N2 - BACKGROUND: Most investigators have hypothesized that the increase in mortality following osteoporotic fractures reflects poor underlying health status in addition to the acute effects of the fracture. METHODS: We observed 9704 ambulatory women aged 65 years or older enrolled in the Study of Osteoporotic Fractures. We obtained reports of fractures and deaths every 4 months and reviewed death certificates and hospital discharge summaries. Multivariable proportional hazards models were used to determine the association between fractures and age-adjusted mortality. RESULTS: During a mean follow-up of 5.9 years, 1737 women had nonspine fractures, with a postfracture mortality rate of 3 per 100 woman-years, compared with 1.8 per 100 woman-years in those who did not have fractures (P < .001). After adjusting for other factors associated with mortality, women (n = 361) with fractures of the hip or pelvis had a 2.4-fold (95% confidence interval, 1.7-3.3) increase in mortality. However, only 9 (14%) of the 64 deaths that occurred after hip or pelvic fractures were caused or hastened by the fracture. By contrast, 11 (17%) of these deaths seemed to have been a result of chronic conditions that has contributed to the hip or pelvic fracture, and 44 (69%) of the deaths were not clearly related to the fracture. CONCLUSIONS: Mortality is increased following several types of fractures in older women. Most of the increase following hip and pelvic fractures is due to underlying conditions and probably would not be affected by reductions in the incidence of these fractures. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/8687260/Mortality_following_fractures_in_older_women__The_study_of_osteoporotic_fractures_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/156/pg/1521 DB - PRIME DP - Unbound Medicine ER -