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Augmentation strategies: focus on anxiolytics.
J Clin Psychiatry 1996; 57 Suppl 7:25-31; discussion 32-3JC

Abstract

Approximately 20% to 40% of patients will fail to respond to the first antidepressant used for their current major depressive episode. Furthermore, it has been suggested that a further 20% to 30% of patients will have only a partial response. There are four main options to consider in the treatment of these patients: optimization, substitution, augmentation, and combination therapy. Several combination antidepressant treatments have been used in treatment-refractory depression. Moreover, various augmentation strategies have also proved to be successful. Although the empirical data to support these treatment options are limited, augmentation treatment has several potential advantages over the other clinical options available, particularly substitution. These data are reviewed and clinical applications discussed. Particular attention is paid to the role of anxiolytics as augmentation agents in the treatment of major depression.

Authors+Show Affiliations

Regional Mood Disorders Program, Hamilton Psychiatric Hospital, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8690693

Citation

Joffe, R T., et al. "Augmentation Strategies: Focus On Anxiolytics." The Journal of Clinical Psychiatry, vol. 57 Suppl 7, 1996, pp. 25-31; discussion 32-3.
Joffe RT, Levitt AJ, Sokolov ST. Augmentation strategies: focus on anxiolytics. J Clin Psychiatry. 1996;57 Suppl 7:25-31; discussion 32-3.
Joffe, R. T., Levitt, A. J., & Sokolov, S. T. (1996). Augmentation strategies: focus on anxiolytics. The Journal of Clinical Psychiatry, 57 Suppl 7, pp. 25-31; discussion 32-3.
Joffe RT, Levitt AJ, Sokolov ST. Augmentation Strategies: Focus On Anxiolytics. J Clin Psychiatry. 1996;57 Suppl 7:25-31; discussion 32-3. PubMed PMID: 8690693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Augmentation strategies: focus on anxiolytics. AU - Joffe,R T, AU - Levitt,A J, AU - Sokolov,S T, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 25-31; discussion 32-3 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 57 Suppl 7 N2 - Approximately 20% to 40% of patients will fail to respond to the first antidepressant used for their current major depressive episode. Furthermore, it has been suggested that a further 20% to 30% of patients will have only a partial response. There are four main options to consider in the treatment of these patients: optimization, substitution, augmentation, and combination therapy. Several combination antidepressant treatments have been used in treatment-refractory depression. Moreover, various augmentation strategies have also proved to be successful. Although the empirical data to support these treatment options are limited, augmentation treatment has several potential advantages over the other clinical options available, particularly substitution. These data are reviewed and clinical applications discussed. Particular attention is paid to the role of anxiolytics as augmentation agents in the treatment of major depression. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/8690693/Augmentation_strategies:_focus_on_anxiolytics_ L2 - https://medlineplus.gov/antidepressants.html DB - PRIME DP - Unbound Medicine ER -