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Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy-verified series.
Med J Aust 1996; 165(2):77-80MJ

Abstract

OBJECTIVE

To determine the relationship between the apolipoprotein E epsilon 4 allele and autopsy-verified Alzheimer's disease (AD) in an Australian population.

DESIGN

Retrospective case-control study.

SETTING

Royal Perth Hospital, Perth, Western Australia (a tertiary referral hospital).

SUBJECTS

50 subjects with "definite" AD (according to the histological and clinical criteria of the Consortium to Establish a Registry for Alzheimer's Disease [CERAD]) and 30 control subjects who had died from a non-neurological disease were randomly selected from the hospital's neuropathology register.

OUTCOME MEASURES

Histological grading of brain sections stained with the modified Bielschowsky stain according to the criteria of CERAD; number (burden) of neuritic plaques; apolipoprotein E genotype (APOE).

RESULTS

Frequency of the epsilon 4 allele was significantly higher in the AD group (37%) than in the control group (2%) (chi 2 = 25.8; P < 0.00001). In the AD group, 50% of subjects were heterozygous for the epsilon 4 allele and 12% were homozygous, while in the control group one subject was heterozygous for the allele and none were homozygous. No association was seen between the epsilon 4 allele and neuritic plaque burden in the hippocampus, entorhinal cortex, middle frontal gyrus or inferior parietal lobule in subjects with AD.

CONCLUSIONS

Our findings confirm an association between the epsilon 4 allele and autopsy-verified AD. The epsilon 4 allele may be an important risk factor for susceptibility to AD in the general Australian population.

Authors+Show Affiliations

Department of Neuropathology, Royal Perth Hospital, WA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8692066

Citation

Fabian, V A., et al. "Alzheimer's Disease and Apolipoprotein E Genotype in Western Australia: an Autopsy-verified Series." The Medical Journal of Australia, vol. 165, no. 2, 1996, pp. 77-80.
Fabian VA, Jones TM, Wilton SD, et al. Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy-verified series. Med J Aust. 1996;165(2):77-80.
Fabian, V. A., Jones, T. M., Wilton, S. D., Dench, J. E., Davis, M. R., Lim, L., & Kakulas, B. A. (1996). Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy-verified series. The Medical Journal of Australia, 165(2), pp. 77-80.
Fabian VA, et al. Alzheimer's Disease and Apolipoprotein E Genotype in Western Australia: an Autopsy-verified Series. Med J Aust. 1996 Jul 15;165(2):77-80. PubMed PMID: 8692066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy-verified series. AU - Fabian,V A, AU - Jones,T M, AU - Wilton,S D, AU - Dench,J E, AU - Davis,M R, AU - Lim,L, AU - Kakulas,B A, PY - 1996/7/15/pubmed PY - 1996/7/15/medline PY - 1996/7/15/entrez SP - 77 EP - 80 JF - The Medical journal of Australia JO - Med. J. Aust. VL - 165 IS - 2 N2 - OBJECTIVE: To determine the relationship between the apolipoprotein E epsilon 4 allele and autopsy-verified Alzheimer's disease (AD) in an Australian population. DESIGN: Retrospective case-control study. SETTING: Royal Perth Hospital, Perth, Western Australia (a tertiary referral hospital). SUBJECTS: 50 subjects with "definite" AD (according to the histological and clinical criteria of the Consortium to Establish a Registry for Alzheimer's Disease [CERAD]) and 30 control subjects who had died from a non-neurological disease were randomly selected from the hospital's neuropathology register. OUTCOME MEASURES: Histological grading of brain sections stained with the modified Bielschowsky stain according to the criteria of CERAD; number (burden) of neuritic plaques; apolipoprotein E genotype (APOE). RESULTS: Frequency of the epsilon 4 allele was significantly higher in the AD group (37%) than in the control group (2%) (chi 2 = 25.8; P < 0.00001). In the AD group, 50% of subjects were heterozygous for the epsilon 4 allele and 12% were homozygous, while in the control group one subject was heterozygous for the allele and none were homozygous. No association was seen between the epsilon 4 allele and neuritic plaque burden in the hippocampus, entorhinal cortex, middle frontal gyrus or inferior parietal lobule in subjects with AD. CONCLUSIONS: Our findings confirm an association between the epsilon 4 allele and autopsy-verified AD. The epsilon 4 allele may be an important risk factor for susceptibility to AD in the general Australian population. SN - 0025-729X UR - https://www.unboundmedicine.com/medline/citation/8692066/Alzheimer's_disease_and_apolipoprotein_E_genotype_in_Western_Australia:_an_autopsy_verified_series_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0025-729X&amp;date=1996&amp;volume=165&amp;issue=2&amp;spage=77 DB - PRIME DP - Unbound Medicine ER -