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Serum leptin in children with obesity: relationship to gender and development.
Pediatrics 1996; 98(2 Pt 1):201-3Ped

Abstract

BACKGROUND

The identification of the ob gene and its adipocyte-specific protein leptin has provided the first physiologic links to the regulatory system controlling body weight. In adults, elevations of serum leptin concentrations were closely correlated with the percentage of body fat. This study investigated whether leptin concentrations were elevated in obese children and the relationship between leptin concentrations and gender, pubertal stage, and race.

METHODS

Seventy-seven children (44 girls and 33 boys), mean age, 11.3 years, with a body mass indices (BMIs) greater than 95% for age, race, and gender (mean BMI, 34.4) constituted the obese group. Thirty children (20 girls and 10 boys), mean age, 13.3 years, with BMIs less than 85% for age, race, and sex formed the control group. Radioimmunoassay for serum leptin was performed on a blood sample collected from each child after an overnight fast.

RESULTS

The mean serum concentration of leptin in the obese group was 38.6 (SD, 21) ng/mL compared with 7.8 (SD, 6.5) ng/mL in the control group. Serum leptin concentrations were highly correlated with BMI (r = .88). Analysis of covariance revealed a main effect for Tanner stage and gender.

CONCLUSIONS

As in adults, obese children have high concentrations of serum leptin, which were highly correlated with arm fat and BMI. Increased adipose tissue in children is associated directly with serum leptin concentration. Leptin concentrations were found to vary with Tanner stage independent of adiposity. Compared with boys, girls had increased leptin concentrations independent of adiposity. It was hypothesized that children manifest a relative "leptin resistance" to support increased growth and development of reproductive capacity.

Authors+Show Affiliations

Department of Pediatrics, Alfred I duPont Institute, Wilmington, DE 19899, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8692618

Citation

Hassink, S G., et al. "Serum Leptin in Children With Obesity: Relationship to Gender and Development." Pediatrics, vol. 98, no. 2 Pt 1, 1996, pp. 201-3.
Hassink SG, Sheslow DV, de Lancey E, et al. Serum leptin in children with obesity: relationship to gender and development. Pediatrics. 1996;98(2 Pt 1):201-3.
Hassink, S. G., Sheslow, D. V., de Lancey, E., Opentanova, I., Considine, R. V., & Caro, J. F. (1996). Serum leptin in children with obesity: relationship to gender and development. Pediatrics, 98(2 Pt 1), pp. 201-3.
Hassink SG, et al. Serum Leptin in Children With Obesity: Relationship to Gender and Development. Pediatrics. 1996;98(2 Pt 1):201-3. PubMed PMID: 8692618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin in children with obesity: relationship to gender and development. AU - Hassink,S G, AU - Sheslow,D V, AU - de Lancey,E, AU - Opentanova,I, AU - Considine,R V, AU - Caro,J F, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 201 EP - 3 JF - Pediatrics JO - Pediatrics VL - 98 IS - 2 Pt 1 N2 - BACKGROUND: The identification of the ob gene and its adipocyte-specific protein leptin has provided the first physiologic links to the regulatory system controlling body weight. In adults, elevations of serum leptin concentrations were closely correlated with the percentage of body fat. This study investigated whether leptin concentrations were elevated in obese children and the relationship between leptin concentrations and gender, pubertal stage, and race. METHODS: Seventy-seven children (44 girls and 33 boys), mean age, 11.3 years, with a body mass indices (BMIs) greater than 95% for age, race, and gender (mean BMI, 34.4) constituted the obese group. Thirty children (20 girls and 10 boys), mean age, 13.3 years, with BMIs less than 85% for age, race, and sex formed the control group. Radioimmunoassay for serum leptin was performed on a blood sample collected from each child after an overnight fast. RESULTS: The mean serum concentration of leptin in the obese group was 38.6 (SD, 21) ng/mL compared with 7.8 (SD, 6.5) ng/mL in the control group. Serum leptin concentrations were highly correlated with BMI (r = .88). Analysis of covariance revealed a main effect for Tanner stage and gender. CONCLUSIONS: As in adults, obese children have high concentrations of serum leptin, which were highly correlated with arm fat and BMI. Increased adipose tissue in children is associated directly with serum leptin concentration. Leptin concentrations were found to vary with Tanner stage independent of adiposity. Compared with boys, girls had increased leptin concentrations independent of adiposity. It was hypothesized that children manifest a relative "leptin resistance" to support increased growth and development of reproductive capacity. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/8692618/Serum_leptin_in_children_with_obesity:_relationship_to_gender_and_development_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=8692618 DB - PRIME DP - Unbound Medicine ER -