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Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly.
Am J Clin Nutr 1996; 64(2):190-6AJ

Abstract

We examined vitamin E and vitamin C supplement use in relation to mortality risk and whether vitamin C enhanced the effects of vitamin E in 11,178 persons aged 67-105 y who participated in the Established Populations for Epidemiologic Studies of the Elderly in 1984-1993. Participants were asked to report all nonprescription drugs currently used, including vitamin supplements. Persons were defined as users of these supplements if they reported individual vitamin E and/or vitamin C use, not part of a multivitamin. During the follow-up period there were 3490 deaths. Use of vitamin E reduced the risk of all-cause mortality [relative risk (RR) = 0.66; 95% CI: 0.53, 0.83] and risk of coronary disease mortality (RR = 0.53; 95% CI: 0.34, 0.84). Use of vitamin E at two points in time was also associated with reduced risk of total mortality compared with that in persons who did not use any vitamin supplements. Effects were strongest for coronary heart disease mortality (RR = 0.37; 95% CI: 0.15, 0.90). The RR for cancer mortality was 0.41 (95% CI: 0.15, 1.08). Simultaneous use of vitamins E and C was associated with a lower risk of total mortality (RR = 0.58; 95% CI: 0.42, 0.79) and coronary mortality (RR = 0.47; 95% CI: 0.25, 0.87). Adjustment for alcohol use, smoking history, aspirin use, and medical conditions did not substantially alter these findings. These findings are consistent with those for younger persons and suggest protective effects of vitamin E supplements in the elderly.

Authors+Show Affiliations

Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD 20892-9205, USA. klosoncz@gibbs.oit.unc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8694019

Citation

Losonczy, K G., et al. "Vitamin E and Vitamin C Supplement Use and Risk of All-cause and Coronary Heart Disease Mortality in Older Persons: the Established Populations for Epidemiologic Studies of the Elderly." The American Journal of Clinical Nutrition, vol. 64, no. 2, 1996, pp. 190-6.
Losonczy KG, Harris TB, Havlik RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr. 1996;64(2):190-6.
Losonczy, K. G., Harris, T. B., & Havlik, R. J. (1996). Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. The American Journal of Clinical Nutrition, 64(2), pp. 190-6.
Losonczy KG, Harris TB, Havlik RJ. Vitamin E and Vitamin C Supplement Use and Risk of All-cause and Coronary Heart Disease Mortality in Older Persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr. 1996;64(2):190-6. PubMed PMID: 8694019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. AU - Losonczy,K G, AU - Harris,T B, AU - Havlik,R J, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 190 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 64 IS - 2 N2 - We examined vitamin E and vitamin C supplement use in relation to mortality risk and whether vitamin C enhanced the effects of vitamin E in 11,178 persons aged 67-105 y who participated in the Established Populations for Epidemiologic Studies of the Elderly in 1984-1993. Participants were asked to report all nonprescription drugs currently used, including vitamin supplements. Persons were defined as users of these supplements if they reported individual vitamin E and/or vitamin C use, not part of a multivitamin. During the follow-up period there were 3490 deaths. Use of vitamin E reduced the risk of all-cause mortality [relative risk (RR) = 0.66; 95% CI: 0.53, 0.83] and risk of coronary disease mortality (RR = 0.53; 95% CI: 0.34, 0.84). Use of vitamin E at two points in time was also associated with reduced risk of total mortality compared with that in persons who did not use any vitamin supplements. Effects were strongest for coronary heart disease mortality (RR = 0.37; 95% CI: 0.15, 0.90). The RR for cancer mortality was 0.41 (95% CI: 0.15, 1.08). Simultaneous use of vitamins E and C was associated with a lower risk of total mortality (RR = 0.58; 95% CI: 0.42, 0.79) and coronary mortality (RR = 0.47; 95% CI: 0.25, 0.87). Adjustment for alcohol use, smoking history, aspirin use, and medical conditions did not substantially alter these findings. These findings are consistent with those for younger persons and suggest protective effects of vitamin E supplements in the elderly. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/8694019/Vitamin_E_and_vitamin_C_supplement_use_and_risk_of_all_cause_and_coronary_heart_disease_mortality_in_older_persons:_the_Established_Populations_for_Epidemiologic_Studies_of_the_Elderly_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/64.2.190 DB - PRIME DP - Unbound Medicine ER -