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Differential regional and kinetics effects of piribedil and bromocriptine on dopamine metabolites: a brain microdialysis study in freely moving rats.
J Neural Transm Gen Sect 1995; 101(1-3):13-26JN

Abstract

Brain microdialysis coupled to HPLC was applied to freely moving rats to investigate the regional kinetics of piribedil and bromocriptine on the extracellular levels of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in striatum, nucleus accumbens, and frontal cortex. Both D2 agonists (20 mg/kg i.p.) decreased DOPAC and HVA in the three brain regions. The responsiveness of frontal cortex to both compounds was greater than those previously reported with other dopaminergic drugs. Regional and temporal differences were observed under piribedil: DOPAC and HVA levels decreased more in the nucleus accumbens than in striatum or frontal cortex but increased over basal values from the 5th hour in the frontal cortex suggesting a late stimulatory effect of piribedil on dopamine synthesis in this area. Such regional effects differentiate piribedil from most other D2 agonists and could explain some behavioural and therapeutic actions possibly related to involvement of nucleus accumbens or/and frontal cortex.

Authors+Show Affiliations

Laboratoire de Physiologie, Faculté de Médecine, Lyon.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8695044

Citation

Pagliari, R, et al. "Differential Regional and Kinetics Effects of Piribedil and Bromocriptine On Dopamine Metabolites: a Brain Microdialysis Study in Freely Moving Rats." Journal of Neural Transmission. General Section, vol. 101, no. 1-3, 1995, pp. 13-26.
Pagliari R, Peyrin L, Crambes O. Differential regional and kinetics effects of piribedil and bromocriptine on dopamine metabolites: a brain microdialysis study in freely moving rats. J Neural Transm Gen Sect. 1995;101(1-3):13-26.
Pagliari, R., Peyrin, L., & Crambes, O. (1995). Differential regional and kinetics effects of piribedil and bromocriptine on dopamine metabolites: a brain microdialysis study in freely moving rats. Journal of Neural Transmission. General Section, 101(1-3), pp. 13-26.
Pagliari R, Peyrin L, Crambes O. Differential Regional and Kinetics Effects of Piribedil and Bromocriptine On Dopamine Metabolites: a Brain Microdialysis Study in Freely Moving Rats. J Neural Transm Gen Sect. 1995;101(1-3):13-26. PubMed PMID: 8695044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential regional and kinetics effects of piribedil and bromocriptine on dopamine metabolites: a brain microdialysis study in freely moving rats. AU - Pagliari,R, AU - Peyrin,L, AU - Crambes,O, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 13 EP - 26 JF - Journal of neural transmission. General section JO - J. Neural Transm. Gen. Sect. VL - 101 IS - 1-3 N2 - Brain microdialysis coupled to HPLC was applied to freely moving rats to investigate the regional kinetics of piribedil and bromocriptine on the extracellular levels of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in striatum, nucleus accumbens, and frontal cortex. Both D2 agonists (20 mg/kg i.p.) decreased DOPAC and HVA in the three brain regions. The responsiveness of frontal cortex to both compounds was greater than those previously reported with other dopaminergic drugs. Regional and temporal differences were observed under piribedil: DOPAC and HVA levels decreased more in the nucleus accumbens than in striatum or frontal cortex but increased over basal values from the 5th hour in the frontal cortex suggesting a late stimulatory effect of piribedil on dopamine synthesis in this area. Such regional effects differentiate piribedil from most other D2 agonists and could explain some behavioural and therapeutic actions possibly related to involvement of nucleus accumbens or/and frontal cortex. UR - https://www.unboundmedicine.com/medline/citation/8695044/Differential_regional_and_kinetics_effects_of_piribedil_and_bromocriptine_on_dopamine_metabolites:_a_brain_microdialysis_study_in_freely_moving_rats_ DB - PRIME DP - Unbound Medicine ER -