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[Significance of CEA and CA242 in the diagnosis of colorectal carcinoma].
Zhonghua Zhong Liu Za Zhi. 1995 Nov; 17(6):438-40.ZZ

Abstract

Carcinoembryonic antigen (CEA) is frequently used in the diagnosis of the colorectal carcinoma. CA242 is a novel unique tumor-associated antigen characterized by higher tumor specificity and sensitivity for colorectal cancer, as compared with other mucin antigens. In this study, preoperative levels of serum CEA and CA242 were measured in 63 cases of colorectal carcinoma. It was disclosed that the positive rate of CA242 was higher than that of CEA, particularly in patients with colon cancer. The combined determination of CEA and CA242 significantly increased the sensitivity and accuracy in the detection of colorectal cancer as compared with the use of CEA alone (P < 0.01). In patients with advanced disease the positive rate was markedly elevated, especially in patients with liver metastasis. The results indicate that the combined use of CEA and CA242 assays is an useful adjunct diagnostic measure for colorectal carcinoma, and is helpful in the assessment of the stage of the disease as well as in making treatment plan.

Authors+Show Affiliations

Department of Abdominal Surgery, Chinese Academy of Medical Sciences, Beijing.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

8697997

Citation

Wu, J, et al. "[Significance of CEA and CA242 in the Diagnosis of Colorectal Carcinoma]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 17, no. 6, 1995, pp. 438-40.
Wu J, Yu H, Shao Y. [Significance of CEA and CA242 in the diagnosis of colorectal carcinoma]. Zhonghua Zhong Liu Za Zhi. 1995;17(6):438-40.
Wu, J., Yu, H., & Shao, Y. (1995). [Significance of CEA and CA242 in the diagnosis of colorectal carcinoma]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 17(6), 438-40.
Wu J, Yu H, Shao Y. [Significance of CEA and CA242 in the Diagnosis of Colorectal Carcinoma]. Zhonghua Zhong Liu Za Zhi. 1995;17(6):438-40. PubMed PMID: 8697997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Significance of CEA and CA242 in the diagnosis of colorectal carcinoma]. AU - Wu,J, AU - Yu,H, AU - Shao,Y, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 438 EP - 40 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 17 IS - 6 N2 - Carcinoembryonic antigen (CEA) is frequently used in the diagnosis of the colorectal carcinoma. CA242 is a novel unique tumor-associated antigen characterized by higher tumor specificity and sensitivity for colorectal cancer, as compared with other mucin antigens. In this study, preoperative levels of serum CEA and CA242 were measured in 63 cases of colorectal carcinoma. It was disclosed that the positive rate of CA242 was higher than that of CEA, particularly in patients with colon cancer. The combined determination of CEA and CA242 significantly increased the sensitivity and accuracy in the detection of colorectal cancer as compared with the use of CEA alone (P < 0.01). In patients with advanced disease the positive rate was markedly elevated, especially in patients with liver metastasis. The results indicate that the combined use of CEA and CA242 assays is an useful adjunct diagnostic measure for colorectal carcinoma, and is helpful in the assessment of the stage of the disease as well as in making treatment plan. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/8697997/[Significance_of_CEA_and_CA242_in_the_diagnosis_of_colorectal_carcinoma]_ DB - PRIME DP - Unbound Medicine ER -