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A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children.
East Afr Med J. 1996 Mar; 73(3):155-8.EA

Abstract

A randomised controlled trial was carried out to determine the relative efficacy of four commonly used antimalarial drugs in children aged three to twelve years presenting with uncomplicated malaria at the Eldoret District Hospital, Kenya. One hundred and eighty eight children were studied between July 1993 and July 1994. There were no significant baseline differences between treatment groups with respect to age, sex, weight, ethnicity, haemoglobin, white blood cell (WBC) counts, parasite counts, previous exposure to malaria and prior treatment. Of the 188 patients, eleven were lost to follow-up while twelve were discontinued from the study due to poor clinical response. Most of the latter (eight out of twelve) were in the chloroquine group. By day seven, there were significant differences (p = 0.004) in parasite clearance between groups. There were no significant statistical differences between the groups (p = 0.12) with regard to the fever clearance time. However, there was a significant statistical difference (p = 0.00003) between the treatment groups in the cure rates. Halofantrine was the most efficacious drug with 82% of the cases cured followed by fansidar(R)(62%), amodiaquine (55%) and chloroquine (29%). RI and RII resistance were observed in all the treatment groups, i.e. halofantrine (18%), fansidar (38%), amodiaquine (45%) and chloroquine (67%) while RIII resistance was only observed in the chloroquine group(3%).

Authors+Show Affiliations

Department of Child Health and Paediatrics, Mol University, Eldoret, Kenya.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8698011

Citation

Anabwani, G M., et al. "A Randomised Controlled Trial to Assess the Relative Efficacy of Chloroquine, Amodiaquine, Halofantrine and Fansidar in the Treatment of Uncomplicated Malaria in Children." East African Medical Journal, vol. 73, no. 3, 1996, pp. 155-8.
Anabwani GM, Esamai FO, Menya DA. A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children. East Afr Med J. 1996;73(3):155-8.
Anabwani, G. M., Esamai, F. O., & Menya, D. A. (1996). A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children. East African Medical Journal, 73(3), 155-8.
Anabwani GM, Esamai FO, Menya DA. A Randomised Controlled Trial to Assess the Relative Efficacy of Chloroquine, Amodiaquine, Halofantrine and Fansidar in the Treatment of Uncomplicated Malaria in Children. East Afr Med J. 1996;73(3):155-8. PubMed PMID: 8698011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children. AU - Anabwani,G M, AU - Esamai,F O, AU - Menya,D A, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 155 EP - 8 JF - East African medical journal JO - East Afr Med J VL - 73 IS - 3 N2 - A randomised controlled trial was carried out to determine the relative efficacy of four commonly used antimalarial drugs in children aged three to twelve years presenting with uncomplicated malaria at the Eldoret District Hospital, Kenya. One hundred and eighty eight children were studied between July 1993 and July 1994. There were no significant baseline differences between treatment groups with respect to age, sex, weight, ethnicity, haemoglobin, white blood cell (WBC) counts, parasite counts, previous exposure to malaria and prior treatment. Of the 188 patients, eleven were lost to follow-up while twelve were discontinued from the study due to poor clinical response. Most of the latter (eight out of twelve) were in the chloroquine group. By day seven, there were significant differences (p = 0.004) in parasite clearance between groups. There were no significant statistical differences between the groups (p = 0.12) with regard to the fever clearance time. However, there was a significant statistical difference (p = 0.00003) between the treatment groups in the cure rates. Halofantrine was the most efficacious drug with 82% of the cases cured followed by fansidar(R)(62%), amodiaquine (55%) and chloroquine (29%). RI and RII resistance were observed in all the treatment groups, i.e. halofantrine (18%), fansidar (38%), amodiaquine (45%) and chloroquine (67%) while RIII resistance was only observed in the chloroquine group(3%). SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/8698011/A_randomised_controlled_trial_to_assess_the_relative_efficacy_of_chloroquine_amodiaquine_halofantrine_and_Fansidar_in_the_treatment_of_uncomplicated_malaria_in_children_ L2 - http://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -