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Antifungal and molluscicidal saponins from Serjania salzmanniana.
J Nat Prod. 1996 Apr; 59(4):431-5.JN

Abstract

An investigation of Serjania salzmanniana for biologically active substances has led to the isolation of two novel saponins, salzmannianoside A (3-O-[[beta-D- glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-alpha-L- arabinopyranosyl] gypsogenin) [3] and salzmannianoside B (3-O-[[beta-D-glucopyranosyl-(1-->4)]-[alpha-L- arabinopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)] -alpha-L-arabinopyranosyl] hederagenin) (4). Two known saponins, pulsatilla saponin D (3-O-[[beta-D- glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-alpha-L- arabinopyranosyl] hederagenin) (1) and 3-O-[[beta-D-glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-a lpha-L- arabinopyranosyl] oleanolic acid (2) were also isolated from this plant. The structures of 3 and 4 were elucidated by FABMS and 2D NMR techniques. All these four saponins were mollusicidal, causing 70-100% mortality at 10 ppm against Biomphalaria alexandrina, a vector of Schistosoma mansoni in the Nile Valley. The saponins also showed antifungal activity against Cryptococcus neoformans and Candida albicans at minimal inhibitory concentrations of 8 and 16 micrograms/mL, respectively.

Authors+Show Affiliations

Ekabo OA
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago 60612, USA.
Farnsworth NR
No affiliation info available
Henderson TO
No affiliation info available
Mao G
No affiliation info available
Mukherjee R
No affiliation info available

MeSH

AnimalsAntifungal AgentsBiomphalariaCandida albicansCryptococcus neoformansEthiopiaMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolluscacidesPlants, MedicinalSaponinsSpectrometry, Mass, Fast Atom Bombardment

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8699187

Citation

Ekabo, O A., et al. "Antifungal and Molluscicidal Saponins From Serjania Salzmanniana." Journal of Natural Products, vol. 59, no. 4, 1996, pp. 431-5.
Ekabo OA, Farnsworth NR, Henderson TO, et al. Antifungal and molluscicidal saponins from Serjania salzmanniana. J Nat Prod. 1996;59(4):431-5.
Ekabo, O. A., Farnsworth, N. R., Henderson, T. O., Mao, G., & Mukherjee, R. (1996). Antifungal and molluscicidal saponins from Serjania salzmanniana. Journal of Natural Products, 59(4), 431-5.
Ekabo OA, et al. Antifungal and Molluscicidal Saponins From Serjania Salzmanniana. J Nat Prod. 1996;59(4):431-5. PubMed PMID: 8699187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal and molluscicidal saponins from Serjania salzmanniana. AU - Ekabo,O A, AU - Farnsworth,N R, AU - Henderson,T O, AU - Mao,G, AU - Mukherjee,R, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 431 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 59 IS - 4 N2 - An investigation of Serjania salzmanniana for biologically active substances has led to the isolation of two novel saponins, salzmannianoside A (3-O-[[beta-D- glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-alpha-L- arabinopyranosyl] gypsogenin) [3] and salzmannianoside B (3-O-[[beta-D-glucopyranosyl-(1-->4)]-[alpha-L- arabinopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)] -alpha-L-arabinopyranosyl] hederagenin) (4). Two known saponins, pulsatilla saponin D (3-O-[[beta-D- glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-alpha-L- arabinopyranosyl] hederagenin) (1) and 3-O-[[beta-D-glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-a lpha-L- arabinopyranosyl] oleanolic acid (2) were also isolated from this plant. The structures of 3 and 4 were elucidated by FABMS and 2D NMR techniques. All these four saponins were mollusicidal, causing 70-100% mortality at 10 ppm against Biomphalaria alexandrina, a vector of Schistosoma mansoni in the Nile Valley. The saponins also showed antifungal activity against Cryptococcus neoformans and Candida albicans at minimal inhibitory concentrations of 8 and 16 micrograms/mL, respectively. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/8699187/Antifungal_and_molluscicidal_saponins_from_Serjania_salzmanniana_ L2 - https://doi.org/10.1021/np960208r DB - PRIME DP - Unbound Medicine ER -