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[Potassium channel openers antagonize 4-aminopyridine induced histamine release from rat peritoneal mast cells].
Yao Xue Xue Bao. 1995; 30(10):736-40.YX

Abstract

4-Aminopyridine (4-AP) was shown to promote histamine release from isolated rat peritoneal mast cells (PMC) in a dose-dependent manner. Potassium channel openers, minoxidil (Min) 200 mg.kg-1 ig, diazoxide (Dia) 500 mumol.L-1 in vitro and calcium antagonist nifedipine (Nif) 125 mg.kg-1 ig were found to inhibit 4-AP induced histamine release from rat PMC. Electron microscopy revealed that 4-AP caused partial degranulation of PMC and extrusion of granules and Min 200 mg.kg-1 ig retarded this phenomenon. These results provide evidence that potassium channels are present in rat mast cell membrane and indicate that the mechanism of histamine release by 4-AP may be related to its potassium channel blocking effect. As a result of this effect, the calcium channels open and Ca2+ influx to the mast cells increases, thus eliciting histamine release. Potassium channel openers seemed to be a new group of inhibitors of histamine release from mast cells.

Authors+Show Affiliations

Department of Pharmacology, Zhejiang Medical University, Hangzhon.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

8701728

Citation

Chen, Z G., and J H. Xu. "[Potassium Channel Openers Antagonize 4-aminopyridine Induced Histamine Release From Rat Peritoneal Mast Cells]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 30, no. 10, 1995, pp. 736-40.
Chen ZG, Xu JH. [Potassium channel openers antagonize 4-aminopyridine induced histamine release from rat peritoneal mast cells]. Yao Xue Xue Bao. 1995;30(10):736-40.
Chen, Z. G., & Xu, J. H. (1995). [Potassium channel openers antagonize 4-aminopyridine induced histamine release from rat peritoneal mast cells]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 30(10), 736-40.
Chen ZG, Xu JH. [Potassium Channel Openers Antagonize 4-aminopyridine Induced Histamine Release From Rat Peritoneal Mast Cells]. Yao Xue Xue Bao. 1995;30(10):736-40. PubMed PMID: 8701728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Potassium channel openers antagonize 4-aminopyridine induced histamine release from rat peritoneal mast cells]. AU - Chen,Z G, AU - Xu,J H, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 736 EP - 40 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 30 IS - 10 N2 - 4-Aminopyridine (4-AP) was shown to promote histamine release from isolated rat peritoneal mast cells (PMC) in a dose-dependent manner. Potassium channel openers, minoxidil (Min) 200 mg.kg-1 ig, diazoxide (Dia) 500 mumol.L-1 in vitro and calcium antagonist nifedipine (Nif) 125 mg.kg-1 ig were found to inhibit 4-AP induced histamine release from rat PMC. Electron microscopy revealed that 4-AP caused partial degranulation of PMC and extrusion of granules and Min 200 mg.kg-1 ig retarded this phenomenon. These results provide evidence that potassium channels are present in rat mast cell membrane and indicate that the mechanism of histamine release by 4-AP may be related to its potassium channel blocking effect. As a result of this effect, the calcium channels open and Ca2+ influx to the mast cells increases, thus eliciting histamine release. Potassium channel openers seemed to be a new group of inhibitors of histamine release from mast cells. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/8701728/[Potassium_channel_openers_antagonize_4_aminopyridine_induced_histamine_release_from_rat_peritoneal_mast_cells]_ L2 - https://antibodies.cancer.gov/detail/CPTC-S100A9-1 DB - PRIME DP - Unbound Medicine ER -