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Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial.
Gynecol Endocrinol. 1996 Apr; 10(2):119-23.GE

Abstract

The objective of this study was to compare the efficacy of flutamide and cyproterone acetate in the treatment of hirsutism. Twenty-two women with idiopathic hirsutism were randomized to receive either flutamide or cyproterone acetate. Each patient underwent a complete gynecological examination as well as an endocrinological profile and hematological, hepatic and renal function analyses. Hirsutism scores were determined using a modified Ferriman-Gallwey scoring system. These tests were then repeated at 3 and 9 months of therapy. Eleven patients received 250 mg of flutamide twice daily and 11 patients received 100 mg of cyproterone acetate on days 5-14 of the menstrual cycle. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. There was a trend towards a better response with flutamide, that did not achieve significance. Another significant difference was the increased sex hormone-binding globulin in both groups. A statistically significant decrease was also observed for the levels of testosterone on both drugs. No subject withdrew from the study due to a side-effect. The data suggest that both flutamide and cyproterone acetate were similarly effective in treatment of hirsutism, and that the pure antiandrogen flutamide is a safe, well-tolerated and effective alternative in treatment.

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Authors+Show Affiliations

Grigoriou O
Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Papadias C
No affiliation info available
Konidaris S
No affiliation info available
Antoniou G
No affiliation info available
Karakitsos P
No affiliation info available
Giannikos L
No affiliation info available

MeSH

AdolescentAdultAndrogen AntagonistsCyproteroneFemaleFlutamideHirsutismHormonesHumansProspective Studies

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8701785

Citation

Grigoriou, O, et al. "Comparison of Flutamide and Cyproterone Acetate in the Treatment of Hirsutism: a Randomized Controlled Trial." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 10, no. 2, 1996, pp. 119-23.
Grigoriou O, Papadias C, Konidaris S, et al. Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial. Gynecol Endocrinol. 1996;10(2):119-23.
Grigoriou, O., Papadias, C., Konidaris, S., Antoniou, G., Karakitsos, P., & Giannikos, L. (1996). Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 10(2), 119-23.
Grigoriou O, et al. Comparison of Flutamide and Cyproterone Acetate in the Treatment of Hirsutism: a Randomized Controlled Trial. Gynecol Endocrinol. 1996;10(2):119-23. PubMed PMID: 8701785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial. AU - Grigoriou,O, AU - Papadias,C, AU - Konidaris,S, AU - Antoniou,G, AU - Karakitsos,P, AU - Giannikos,L, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 119 EP - 23 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 10 IS - 2 N2 - The objective of this study was to compare the efficacy of flutamide and cyproterone acetate in the treatment of hirsutism. Twenty-two women with idiopathic hirsutism were randomized to receive either flutamide or cyproterone acetate. Each patient underwent a complete gynecological examination as well as an endocrinological profile and hematological, hepatic and renal function analyses. Hirsutism scores were determined using a modified Ferriman-Gallwey scoring system. These tests were then repeated at 3 and 9 months of therapy. Eleven patients received 250 mg of flutamide twice daily and 11 patients received 100 mg of cyproterone acetate on days 5-14 of the menstrual cycle. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. There was a trend towards a better response with flutamide, that did not achieve significance. Another significant difference was the increased sex hormone-binding globulin in both groups. A statistically significant decrease was also observed for the levels of testosterone on both drugs. No subject withdrew from the study due to a side-effect. The data suggest that both flutamide and cyproterone acetate were similarly effective in treatment of hirsutism, and that the pure antiandrogen flutamide is a safe, well-tolerated and effective alternative in treatment. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/8701785/Comparison_of_flutamide_and_cyproterone_acetate_in_the_treatment_of_hirsutism:_a_randomized_controlled_trial_ L2 - https://www.tandfonline.com/doi/full/10.3109/09513599609097901 DB - PRIME DP - Unbound Medicine ER -