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Platelet-activating factor and haematopoiesis. XI. Platelet-activating factor has no effect on the production of interleukin-6 and tumor necrosis factor-alpha by human bone marrow stromal cells.
Eur Cytokine Netw. 1996 Jan-Mar; 7(1):75-7.EC

Abstract

PAF is a phospholipid mediator of inflammation with stimulates IL-6 production by murine skin fibroblasts. Although PAF is present in human bone marrow, its role in haematopoiesis is unknown. We have assessed whether PAF stimulates IL-6 and TNF-alpha production by human bone marrow stromal cells (mostly fibroblast-like cells). We report that PAF (1 nM to 10 microM) has no effect on the synthesis of IL-6 and TNF-alpha by human bone marrow stromal cells. This difference may be due to the widely accepted concept "tissue-specific fibroblasts". The role of PAF in the regulation of human haematopoiesis remains to be elucidated.

Authors+Show Affiliations

Denizot Y
Laboratoire d Hématologie Expérimentale, Faculté de Médecine, Limoges France.
Rougier F
No affiliation info available
Cornu E
No affiliation info available
Praloran V
No affiliation info available

MeSH

Bone MarrowBone Marrow CellsCells, CulturedHematopoiesisHumansInterleukin-6Platelet Activating FactorStromal CellsTumor Necrosis Factor-alpha

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8704099

Citation

Denizot, Y, et al. "Platelet-activating Factor and Haematopoiesis. XI. Platelet-activating Factor Has No Effect On the Production of Interleukin-6 and Tumor Necrosis Factor-alpha By Human Bone Marrow Stromal Cells." European Cytokine Network, vol. 7, no. 1, 1996, pp. 75-7.
Denizot Y, Rougier F, Cornu E, et al. Platelet-activating factor and haematopoiesis. XI. Platelet-activating factor has no effect on the production of interleukin-6 and tumor necrosis factor-alpha by human bone marrow stromal cells. Eur Cytokine Netw. 1996;7(1):75-7.
Denizot, Y., Rougier, F., Cornu, E., & Praloran, V. (1996). Platelet-activating factor and haematopoiesis. XI. Platelet-activating factor has no effect on the production of interleukin-6 and tumor necrosis factor-alpha by human bone marrow stromal cells. European Cytokine Network, 7(1), 75-7.
Denizot Y, et al. Platelet-activating Factor and Haematopoiesis. XI. Platelet-activating Factor Has No Effect On the Production of Interleukin-6 and Tumor Necrosis Factor-alpha By Human Bone Marrow Stromal Cells. Eur Cytokine Netw. 1996 Jan-Mar;7(1):75-7. PubMed PMID: 8704099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Platelet-activating factor and haematopoiesis. XI. Platelet-activating factor has no effect on the production of interleukin-6 and tumor necrosis factor-alpha by human bone marrow stromal cells. AU - Denizot,Y, AU - Rougier,F, AU - Cornu,E, AU - Praloran,V, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 75 EP - 7 JF - European cytokine network JO - Eur Cytokine Netw VL - 7 IS - 1 N2 - PAF is a phospholipid mediator of inflammation with stimulates IL-6 production by murine skin fibroblasts. Although PAF is present in human bone marrow, its role in haematopoiesis is unknown. We have assessed whether PAF stimulates IL-6 and TNF-alpha production by human bone marrow stromal cells (mostly fibroblast-like cells). We report that PAF (1 nM to 10 microM) has no effect on the synthesis of IL-6 and TNF-alpha by human bone marrow stromal cells. This difference may be due to the widely accepted concept "tissue-specific fibroblasts". The role of PAF in the regulation of human haematopoiesis remains to be elucidated. SN - 1148-5493 UR - https://www.unboundmedicine.com/medline/citation/8704099/Platelet_activating_factor_and_haematopoiesis__XI__Platelet_activating_factor_has_no_effect_on_the_production_of_interleukin_6_and_tumor_necrosis_factor_alpha_by_human_bone_marrow_stromal_cells_ L2 - http://www.diseaseinfosearch.org/result/9545 DB - PRIME DP - Unbound Medicine ER -