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Critical illness polyneuropathy: clinical findings and outcomes of a frequent cause of neuromuscular weaning failure.
Crit Care Med. 1996 Aug; 24(8):1328-33.CC

Abstract

OBJECTIVE

To describe clinical and electrophysiologic features and outcomes of critically ill patients with neuromuscular causes of failure to wean from mechanical ventilator support.

DESIGN

A prospective, consecutive, case series.

SETTING

Neurological, neurosurgical, and medical intensive care units in a university hospital.

PATIENTS

Seven patients during a 3-yr period with failure to wean from mechanical ventilation not explained by pulmonary complications.

INTERVENTIONS

Muscle and nerve biopsy in three patients.

MEASUREMENTS AND MAIN RESULTS

Detailed electrodiagnostic studies were done in all patients 3 to 6 wks (median 4.5) after the onset of the acute illness and were repeated 3 months to 3.5 yrs later in those patients who survived. Primary illnesses included various intracranial and medical conditions. All patients had moderate-to-severe limb weakness with marked muscle atrophy. Tendon reflexes were decreased in three patients, exaggerated in two patients with intracranial lesions, and absent in two patients. Electromyography demonstrated severe acute denervation, with striking involvement of proximal muscles. Muscle and nerve biopsies showed severe neurogenic atrophy and axonal degeneration without inflammation. There was no evidence of primary myopathy. Two patients died of complications of sepsis. Of the survivors, three patients had no further weakness at the time of reexamination, except for peroneal nerve palsy in one patient. Two patients, still in the recovery period, showed markedly improved conditions but still showed slight weakness of the proximal muscles. By electrophysiology, signs of chronic neurogenic damage were demonstrable in all survivors at follow-up.

CONCLUSIONS

Critical illness polyneuropathy is a frequent cause of neuromuscular weaning failure in critically ill patients, regardless of the type of primary illness. Involvement of proximal (including facial and paraspinal) muscles is striking. Tendon reflexes are often preserved. Patients with central nervous system injury may likewise develop critical illness polyneuropathy. In these latter patients, tendon reflexes may even be exaggerated. Recovery from critical illness polyneuropathy is usually rapid and clinically complete, although incomplete on electrodiagnostic study. Residual peripheral nerve lesion, generally of the peroneal nerve, is the most frequent feature of incomplete recovery. The need for careful electrophysiologic testing is emphasized to clarify the nature and extent of neuromuscular disturbances in critically ill patients. Failure to recognize the development of neuropathy in these patients may lead to erroneous conclusions about the ability to wean them from the ventilator.

Authors+Show Affiliations

Department of Neurology, Ruprecht-Karis-University, Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8706487

Citation

Hund, E F., et al. "Critical Illness Polyneuropathy: Clinical Findings and Outcomes of a Frequent Cause of Neuromuscular Weaning Failure." Critical Care Medicine, vol. 24, no. 8, 1996, pp. 1328-33.
Hund EF, Fogel W, Krieger D, et al. Critical illness polyneuropathy: clinical findings and outcomes of a frequent cause of neuromuscular weaning failure. Crit Care Med. 1996;24(8):1328-33.
Hund, E. F., Fogel, W., Krieger, D., DeGeorgia, M., & Hacke, W. (1996). Critical illness polyneuropathy: clinical findings and outcomes of a frequent cause of neuromuscular weaning failure. Critical Care Medicine, 24(8), 1328-33.
Hund EF, et al. Critical Illness Polyneuropathy: Clinical Findings and Outcomes of a Frequent Cause of Neuromuscular Weaning Failure. Crit Care Med. 1996;24(8):1328-33. PubMed PMID: 8706487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Critical illness polyneuropathy: clinical findings and outcomes of a frequent cause of neuromuscular weaning failure. AU - Hund,E F, AU - Fogel,W, AU - Krieger,D, AU - DeGeorgia,M, AU - Hacke,W, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 1328 EP - 33 JF - Critical care medicine JO - Crit Care Med VL - 24 IS - 8 N2 - OBJECTIVE: To describe clinical and electrophysiologic features and outcomes of critically ill patients with neuromuscular causes of failure to wean from mechanical ventilator support. DESIGN: A prospective, consecutive, case series. SETTING: Neurological, neurosurgical, and medical intensive care units in a university hospital. PATIENTS: Seven patients during a 3-yr period with failure to wean from mechanical ventilation not explained by pulmonary complications. INTERVENTIONS: Muscle and nerve biopsy in three patients. MEASUREMENTS AND MAIN RESULTS: Detailed electrodiagnostic studies were done in all patients 3 to 6 wks (median 4.5) after the onset of the acute illness and were repeated 3 months to 3.5 yrs later in those patients who survived. Primary illnesses included various intracranial and medical conditions. All patients had moderate-to-severe limb weakness with marked muscle atrophy. Tendon reflexes were decreased in three patients, exaggerated in two patients with intracranial lesions, and absent in two patients. Electromyography demonstrated severe acute denervation, with striking involvement of proximal muscles. Muscle and nerve biopsies showed severe neurogenic atrophy and axonal degeneration without inflammation. There was no evidence of primary myopathy. Two patients died of complications of sepsis. Of the survivors, three patients had no further weakness at the time of reexamination, except for peroneal nerve palsy in one patient. Two patients, still in the recovery period, showed markedly improved conditions but still showed slight weakness of the proximal muscles. By electrophysiology, signs of chronic neurogenic damage were demonstrable in all survivors at follow-up. CONCLUSIONS: Critical illness polyneuropathy is a frequent cause of neuromuscular weaning failure in critically ill patients, regardless of the type of primary illness. Involvement of proximal (including facial and paraspinal) muscles is striking. Tendon reflexes are often preserved. Patients with central nervous system injury may likewise develop critical illness polyneuropathy. In these latter patients, tendon reflexes may even be exaggerated. Recovery from critical illness polyneuropathy is usually rapid and clinically complete, although incomplete on electrodiagnostic study. Residual peripheral nerve lesion, generally of the peroneal nerve, is the most frequent feature of incomplete recovery. The need for careful electrophysiologic testing is emphasized to clarify the nature and extent of neuromuscular disturbances in critically ill patients. Failure to recognize the development of neuropathy in these patients may lead to erroneous conclusions about the ability to wean them from the ventilator. SN - 0090-3493 UR - https://www.unboundmedicine.com/medline/citation/8706487/Critical_illness_polyneuropathy:_clinical_findings_and_outcomes_of_a_frequent_cause_of_neuromuscular_weaning_failure_ L2 - https://dx.doi.org/10.1097/00003246-199608000-00010 DB - PRIME DP - Unbound Medicine ER -