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Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin.
Gut. 1996 May; 38(5):663-7.Gut

Abstract

BACKGROUND

Patients with duodenal ulcer (DU) have high basal (BAO) and peak (PAO) acid outputs. The effect of Helicobacter pylori eradication on these variables is unclear.

AIM

To discover if gastric acid hypersecretion in patients with DU is caused by H pylori.

PATIENTS AND METHODS

BAO, gastrin releasing peptide (GRP), and pentagastrin stimulated PAO in 10 H pylori negative controls, and in 10 H pylori positive patients with DU was measured before and six months after H pylori eradication. H pylori status was determined by histology, culture, and by the 13C-urea breath test. After collecting a 30 minute basal aspirate, GRP 40 pmol/kg/h was infused for 45 minutes, and after a 30 minute washout, pentagastrin 6 micrograms/kg was injected intramuscularly.

RESULTS

Basal and stimulated acid output (PAOGRP and PAOPg) were significantly higher in H pylori positive DU than in H pylori negative controls. Six months after H pylori eradication, basal and stimulated acid outputs were all significantly lower than before H pylori eradication.

CONCLUSIONS

This study has shown that BAO, PAOGRP, and PAOPg are higher in H pylori positive DU than in H pylori negative controls. All decreased significantly six months after H pylori eradication, to fall within the range of controls. These results are compatible with a hypothesis that acid hypersecretion in duodenal ulcer disease is caused by H pylori infection.

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Authors+Show Affiliations

Harris AW
Parkside Helicobacter Study Group, Central Middlesex Hospital, London.
Gummett PA
No affiliation info available
Misiewicz JJ
No affiliation info available
Baron JH
No affiliation info available

MeSH

AdultCase-Control StudiesDuodenal UlcerFemaleGastric AcidGastric JuiceGastrin-Releasing PeptideHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedPentagastrinPeptides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8707109

Citation

Harris, A W., et al. "Eradication of Helicobacter Pylori in Patients With Duodenal Ulcer Lowers Basal and Peak Acid Outputs to Gastrin Releasing Peptide and Pentagastrin." Gut, vol. 38, no. 5, 1996, pp. 663-7.
Harris AW, Gummett PA, Misiewicz JJ, et al. Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin. Gut. 1996;38(5):663-7.
Harris, A. W., Gummett, P. A., Misiewicz, J. J., & Baron, J. H. (1996). Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin. Gut, 38(5), 663-7.
Harris AW, et al. Eradication of Helicobacter Pylori in Patients With Duodenal Ulcer Lowers Basal and Peak Acid Outputs to Gastrin Releasing Peptide and Pentagastrin. Gut. 1996;38(5):663-7. PubMed PMID: 8707109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin. AU - Harris,A W, AU - Gummett,P A, AU - Misiewicz,J J, AU - Baron,J H, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 663 EP - 7 JF - Gut JO - Gut VL - 38 IS - 5 N2 - BACKGROUND: Patients with duodenal ulcer (DU) have high basal (BAO) and peak (PAO) acid outputs. The effect of Helicobacter pylori eradication on these variables is unclear. AIM: To discover if gastric acid hypersecretion in patients with DU is caused by H pylori. PATIENTS AND METHODS: BAO, gastrin releasing peptide (GRP), and pentagastrin stimulated PAO in 10 H pylori negative controls, and in 10 H pylori positive patients with DU was measured before and six months after H pylori eradication. H pylori status was determined by histology, culture, and by the 13C-urea breath test. After collecting a 30 minute basal aspirate, GRP 40 pmol/kg/h was infused for 45 minutes, and after a 30 minute washout, pentagastrin 6 micrograms/kg was injected intramuscularly. RESULTS: Basal and stimulated acid output (PAOGRP and PAOPg) were significantly higher in H pylori positive DU than in H pylori negative controls. Six months after H pylori eradication, basal and stimulated acid outputs were all significantly lower than before H pylori eradication. CONCLUSIONS: This study has shown that BAO, PAOGRP, and PAOPg are higher in H pylori positive DU than in H pylori negative controls. All decreased significantly six months after H pylori eradication, to fall within the range of controls. These results are compatible with a hypothesis that acid hypersecretion in duodenal ulcer disease is caused by H pylori infection. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/8707109/Eradication_of_Helicobacter_pylori_in_patients_with_duodenal_ulcer_lowers_basal_and_peak_acid_outputs_to_gastrin_releasing_peptide_and_pentagastrin_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&pmid=8707109 DB - PRIME DP - Unbound Medicine ER -