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Combined chemotherapy trials with regimens containing ofloxacin and rifampicin for multibacillary leprosy patients.
J Med Assoc Thai. 1996 Apr; 79(4):210-7.JM

Abstract

The results of combined chemotherapy trials with regimens containing ofloxacin and rifampicin for the treatment of 60 multibacillary leprosy cases from January 1989 to September 1995 was reported. Clinical improvement was achieved by all regimens from the end of the first month. Most patients continued to improve for 3 years. Bacterial indices were gradually reduced during the treatment. Patients on regimens containing rifampicin were clear of M. leprae at the end of the 5th year. The complications and side-effects of ofloxacin and rifampicin were trivial and both drugs were well tolerated. Ofloxacin added to the current WHO recommended M.B.-MDT regimen may shorten the duration of treatment. Ofloxacin may be an alternative in suspected/proven rifampicin resistant cases or rifampicin contraindicated.

Authors+Show Affiliations

Phrapradaeng Hospital, Samutprakarn, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8708505

Citation

Sampoonachot, P, et al. "Combined Chemotherapy Trials With Regimens Containing Ofloxacin and Rifampicin for Multibacillary Leprosy Patients." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 79, no. 4, 1996, pp. 210-7.
Sampoonachot P, Bundit C, Kuhacharoen N, et al. Combined chemotherapy trials with regimens containing ofloxacin and rifampicin for multibacillary leprosy patients. J Med Assoc Thai. 1996;79(4):210-7.
Sampoonachot, P., Bundit, C., Kuhacharoen, N., Peerapakorn, S., Kampirapap, K., Poomlek, A., Bampenyu, S., Tiasiri, S., Rungruang, S., Surasondhi, S., Supanwanit, S., & Wiriyawipart, S. (1996). Combined chemotherapy trials with regimens containing ofloxacin and rifampicin for multibacillary leprosy patients. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 79(4), 210-7.
Sampoonachot P, et al. Combined Chemotherapy Trials With Regimens Containing Ofloxacin and Rifampicin for Multibacillary Leprosy Patients. J Med Assoc Thai. 1996;79(4):210-7. PubMed PMID: 8708505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined chemotherapy trials with regimens containing ofloxacin and rifampicin for multibacillary leprosy patients. AU - Sampoonachot,P, AU - Bundit,C, AU - Kuhacharoen,N, AU - Peerapakorn,S, AU - Kampirapap,K, AU - Poomlek,A, AU - Bampenyu,S, AU - Tiasiri,S, AU - Rungruang,S, AU - Surasondhi,S, AU - Supanwanit,S, AU - Wiriyawipart,S, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 210 EP - 7 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 79 IS - 4 N2 - The results of combined chemotherapy trials with regimens containing ofloxacin and rifampicin for the treatment of 60 multibacillary leprosy cases from January 1989 to September 1995 was reported. Clinical improvement was achieved by all regimens from the end of the first month. Most patients continued to improve for 3 years. Bacterial indices were gradually reduced during the treatment. Patients on regimens containing rifampicin were clear of M. leprae at the end of the 5th year. The complications and side-effects of ofloxacin and rifampicin were trivial and both drugs were well tolerated. Ofloxacin added to the current WHO recommended M.B.-MDT regimen may shorten the duration of treatment. Ofloxacin may be an alternative in suspected/proven rifampicin resistant cases or rifampicin contraindicated. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/8708505/Combined_chemotherapy_trials_with_regimens_containing_ofloxacin_and_rifampicin_for_multibacillary_leprosy_patients_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -