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Preventing perinatal transmission of HIV--costs and effectiveness of a recommended intervention.
Public Health Rep. 1996 Jul-Aug; 111(4):335-41.PH

Abstract

OBJECTIVE

To calculate the national costs of reducing perinatal transmission of human immunodeficiency virus through counseling and voluntary testing of pregnant women and zidovudine treatment of infected women and their infants, as recommended by the Public Health Service, and to compare these costs with the savings from reducing the number of pediatric infections.

METHOD

The authors analyzed the estimated costs of the intervention and the estimated cost savings from reducing the number of pediatric infections. The outcome measures are the number of infections prevented by the intervention and the net cost (cost of intervention minus the savings from a reduced number of pediatric HIV infections). The base model assumed that intervention participation and outcomes would resemble those found in the AIDS Clinical Trials Group Protocol 076. Assumptions were varied regarding maternal seroprevalence, participation by HIV-infected women, the proportion of infected women who accepted and completed the treatment, and the efficacy of zidovudine to illustrate the effect of these assumptions on infections prevented and net cost.

RESULTS

Without the intervention, a perinatal HIV transmission rate of 25% would result in 1750 HIV-infected infants born annually in the United States, with lifetime medical-care costs estimated at $282 million. The cost of the intervention (counseling, testing, and zidovudine treatment) was estimated to be $ 67.6 million. In the base model, the intervention would prevent 656 pediatric HIV infections with a medical care cost saving of $105.6 million. The net cost saving of the intervention was $38.1 million.

CONCLUSION

Voluntary HIV screening of pregnant women and ziovudine treatment for infected women and their infants resulted in cost savings under most of the assumptions used in this analysis. These results strongly support implementation of the Public Health Service recommendations for this intervention.

Authors+Show Affiliations

Department of Health Management and Policy, University of New Hampshire, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8711101

Citation

Gorsky, R D., et al. "Preventing Perinatal Transmission of HIV--costs and Effectiveness of a Recommended Intervention." Public Health Reports (Washington, D.C. : 1974), vol. 111, no. 4, 1996, pp. 335-41.
Gorsky RD, Farnham PG, Straus WL, et al. Preventing perinatal transmission of HIV--costs and effectiveness of a recommended intervention. Public Health Rep. 1996;111(4):335-41.
Gorsky, R. D., Farnham, P. G., Straus, W. L., Caldwell, B., Holtgrave, D. R., Simonds, R. J., Rogers, M. F., & Guinan, M. E. (1996). Preventing perinatal transmission of HIV--costs and effectiveness of a recommended intervention. Public Health Reports (Washington, D.C. : 1974), 111(4), 335-41.
Gorsky RD, et al. Preventing Perinatal Transmission of HIV--costs and Effectiveness of a Recommended Intervention. Public Health Rep. 1996 Jul-Aug;111(4):335-41. PubMed PMID: 8711101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preventing perinatal transmission of HIV--costs and effectiveness of a recommended intervention. AU - Gorsky,R D, AU - Farnham,P G, AU - Straus,W L, AU - Caldwell,B, AU - Holtgrave,D R, AU - Simonds,R J, AU - Rogers,M F, AU - Guinan,M E, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 335 EP - 41 JF - Public health reports (Washington, D.C. : 1974) JO - Public Health Rep VL - 111 IS - 4 N2 - OBJECTIVE: To calculate the national costs of reducing perinatal transmission of human immunodeficiency virus through counseling and voluntary testing of pregnant women and zidovudine treatment of infected women and their infants, as recommended by the Public Health Service, and to compare these costs with the savings from reducing the number of pediatric infections. METHOD: The authors analyzed the estimated costs of the intervention and the estimated cost savings from reducing the number of pediatric infections. The outcome measures are the number of infections prevented by the intervention and the net cost (cost of intervention minus the savings from a reduced number of pediatric HIV infections). The base model assumed that intervention participation and outcomes would resemble those found in the AIDS Clinical Trials Group Protocol 076. Assumptions were varied regarding maternal seroprevalence, participation by HIV-infected women, the proportion of infected women who accepted and completed the treatment, and the efficacy of zidovudine to illustrate the effect of these assumptions on infections prevented and net cost. RESULTS: Without the intervention, a perinatal HIV transmission rate of 25% would result in 1750 HIV-infected infants born annually in the United States, with lifetime medical-care costs estimated at $282 million. The cost of the intervention (counseling, testing, and zidovudine treatment) was estimated to be $ 67.6 million. In the base model, the intervention would prevent 656 pediatric HIV infections with a medical care cost saving of $105.6 million. The net cost saving of the intervention was $38.1 million. CONCLUSION: Voluntary HIV screening of pregnant women and ziovudine treatment for infected women and their infants resulted in cost savings under most of the assumptions used in this analysis. These results strongly support implementation of the Public Health Service recommendations for this intervention. SN - 0033-3549 UR - https://www.unboundmedicine.com/medline/citation/8711101/Preventing_perinatal_transmission_of_HIV__costs_and_effectiveness_of_a_recommended_intervention_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8711101/ DB - PRIME DP - Unbound Medicine ER -