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Erythrocytic microcytosis: clinical implications in 100 patients.
Am J Med Sci 1977 Mar-Apr; 273(2):149-55AJ

Abstract

Hematology results from 3800 blood samples were examined for the presence of erythrocytic microcytosis. One hundred patients with electronically measured mean corpuscular volumes of 75 cubic microns or less were reviewed to determine the cause of microcytosis and evaluate recently described simplified techniques for separating thalassemia trait from other causes of microcytosis. The discriminant function formula of England and Fraser [MCV - RBC - (5 x Hgb) - 3.4] was found to be useful in uncomplicated patients with the Mediterranean type of thalassemia trait (betadegree) but less useful in the African type (beta+) of heterozygous beta-thalassemia. Anemias of chronic disorders were found to be a major cause of microcytosis. Microcytosis of no apparent cause was found in some children. Improved techniques in hemoglobin A2 quantification remain the best approach for detecting beta-thalassemia heterozygotes.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

871134

Citation

Cunningham, L O., and J A. Rising. "Erythrocytic Microcytosis: Clinical Implications in 100 Patients." The American Journal of the Medical Sciences, vol. 273, no. 2, 1977, pp. 149-55.
Cunningham LO, Rising JA. Erythrocytic microcytosis: clinical implications in 100 patients. Am J Med Sci. 1977;273(2):149-55.
Cunningham, L. O., & Rising, J. A. (1977). Erythrocytic microcytosis: clinical implications in 100 patients. The American Journal of the Medical Sciences, 273(2), pp. 149-55.
Cunningham LO, Rising JA. Erythrocytic Microcytosis: Clinical Implications in 100 Patients. Am J Med Sci. 1977;273(2):149-55. PubMed PMID: 871134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocytic microcytosis: clinical implications in 100 patients. AU - Cunningham,L O, AU - Rising,J A, PY - 1977/3/1/pubmed PY - 1977/3/1/medline PY - 1977/3/1/entrez SP - 149 EP - 55 JF - The American journal of the medical sciences JO - Am. J. Med. Sci. VL - 273 IS - 2 N2 - Hematology results from 3800 blood samples were examined for the presence of erythrocytic microcytosis. One hundred patients with electronically measured mean corpuscular volumes of 75 cubic microns or less were reviewed to determine the cause of microcytosis and evaluate recently described simplified techniques for separating thalassemia trait from other causes of microcytosis. The discriminant function formula of England and Fraser [MCV - RBC - (5 x Hgb) - 3.4] was found to be useful in uncomplicated patients with the Mediterranean type of thalassemia trait (betadegree) but less useful in the African type (beta+) of heterozygous beta-thalassemia. Anemias of chronic disorders were found to be a major cause of microcytosis. Microcytosis of no apparent cause was found in some children. Improved techniques in hemoglobin A2 quantification remain the best approach for detecting beta-thalassemia heterozygotes. SN - 0002-9629 UR - https://www.unboundmedicine.com/medline/citation/871134/Erythrocytic_microcytosis:_clinical_implications_in_100_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=871134.ui DB - PRIME DP - Unbound Medicine ER -