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Effect of cystathionine and cystathionine metabolites on the phosphorylation of tyrosine residues in human neutrophils.
Biochem Biophys Res Commun. 1996 Jul 25; 224(3):849-54.BB

Abstract

The effect of cystathionine and cystathionine metabolites found in the urine of patients with cystathioninuria on the phosphorylation of tyrosine residues was studied with human peripheral blood polymorphonuclear leukocytes. Among the cystathionine metabolites, cystathionine ketimine markedly increased phosphorylation of a 45 kDa protein with time and the phosphorylation depended on the concentration of cystathionine ketimine, while cystathionine and the reduced form of cystathionine ketimine (cyclothionine) did not increase the phosphorylation of the 45 kDa protein. The phosphorylation of the 45 kDa protein induced by cystathionine ketimine was inhibited by genistein and herbimycin A, inhibitors of tyrosine kinase, but was not inhibited by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and staurosporine, inhibitors of protein kinase C.

Authors+Show Affiliations

Department of Chemistry, Kochi Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8713134

Citation

Zhang, J, et al. "Effect of Cystathionine and Cystathionine Metabolites On the Phosphorylation of Tyrosine Residues in Human Neutrophils." Biochemical and Biophysical Research Communications, vol. 224, no. 3, 1996, pp. 849-54.
Zhang J, Sagara Y, Fontana M, et al. Effect of cystathionine and cystathionine metabolites on the phosphorylation of tyrosine residues in human neutrophils. Biochem Biophys Res Commun. 1996;224(3):849-54.
Zhang, J., Sagara, Y., Fontana, M., Duprè, S., Cavallini, D., & Kodama, H. (1996). Effect of cystathionine and cystathionine metabolites on the phosphorylation of tyrosine residues in human neutrophils. Biochemical and Biophysical Research Communications, 224(3), 849-54.
Zhang J, et al. Effect of Cystathionine and Cystathionine Metabolites On the Phosphorylation of Tyrosine Residues in Human Neutrophils. Biochem Biophys Res Commun. 1996 Jul 25;224(3):849-54. PubMed PMID: 8713134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cystathionine and cystathionine metabolites on the phosphorylation of tyrosine residues in human neutrophils. AU - Zhang,J, AU - Sagara,Y, AU - Fontana,M, AU - Duprè,S, AU - Cavallini,D, AU - Kodama,H, PY - 1996/7/25/pubmed PY - 1996/7/25/medline PY - 1996/7/25/entrez SP - 849 EP - 54 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 224 IS - 3 N2 - The effect of cystathionine and cystathionine metabolites found in the urine of patients with cystathioninuria on the phosphorylation of tyrosine residues was studied with human peripheral blood polymorphonuclear leukocytes. Among the cystathionine metabolites, cystathionine ketimine markedly increased phosphorylation of a 45 kDa protein with time and the phosphorylation depended on the concentration of cystathionine ketimine, while cystathionine and the reduced form of cystathionine ketimine (cyclothionine) did not increase the phosphorylation of the 45 kDa protein. The phosphorylation of the 45 kDa protein induced by cystathionine ketimine was inhibited by genistein and herbimycin A, inhibitors of tyrosine kinase, but was not inhibited by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and staurosporine, inhibitors of protein kinase C. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/8713134/Effect_of_cystathionine_and_cystathionine_metabolites_on_the_phosphorylation_of_tyrosine_residues_in_human_neutrophils_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(96)91111-0 DB - PRIME DP - Unbound Medicine ER -