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Mouse galactokinase: isolation, characterization, and location on chromosome 11.
Genome Res. 1995 Aug; 5(1):53-9.GR

Abstract

Elevated galactose levels can be caused by several enzyme defects, one of which is galactokinase. Galactokinase deficiency cause congenital cataracts during infancy and presenile cataracts in the adult population. We have isolated the mouse cDNA for galactokinase, which shares extensive amino acid sequence homology, 88% identity, with a recently cloned human galactokinase. It is expressed in all tissues examined. In an interspecific backcross analysis galactokinase maps to the distal region of mouse chromosome 11, a region that is homologous to human chromosome 17q22-25. The availability of the mouse gene provides an opportunity to make a knockout model for galactokinase deficiency.

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Authors+Show Affiliations

Ai Y
Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Jenkins NA
No affiliation info available
Copeland NG
No affiliation info available
Gilbert DH
No affiliation info available
Bergsma DJ
No affiliation info available
Stambolian D
No affiliation info available

MeSH

AllelesAmino Acid SequenceAnimalsBase SequenceCell Line, TransformedChlorocebus aethiopsChromosome MappingChromosomes, Human, Pair 17Cloning, MolecularCrosses, GeneticDNA, ComplementaryFemaleGalactokinaseGenesHumansMaleMiceMice, Inbred C57BLMolecular Sequence DataMuridaeSequence AlignmentSequence HomologySpecies Specificity

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8717055

Citation

Ai, Y, et al. "Mouse Galactokinase: Isolation, Characterization, and Location On Chromosome 11." Genome Research, vol. 5, no. 1, 1995, pp. 53-9.
Ai Y, Jenkins NA, Copeland NG, et al. Mouse galactokinase: isolation, characterization, and location on chromosome 11. Genome Res. 1995;5(1):53-9.
Ai, Y., Jenkins, N. A., Copeland, N. G., Gilbert, D. H., Bergsma, D. J., & Stambolian, D. (1995). Mouse galactokinase: isolation, characterization, and location on chromosome 11. Genome Research, 5(1), 53-9.
Ai Y, et al. Mouse Galactokinase: Isolation, Characterization, and Location On Chromosome 11. Genome Res. 1995;5(1):53-9. PubMed PMID: 8717055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mouse galactokinase: isolation, characterization, and location on chromosome 11. AU - Ai,Y, AU - Jenkins,N A, AU - Copeland,N G, AU - Gilbert,D H, AU - Bergsma,D J, AU - Stambolian,D, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 53 EP - 9 JF - Genome research JO - Genome Res VL - 5 IS - 1 N2 - Elevated galactose levels can be caused by several enzyme defects, one of which is galactokinase. Galactokinase deficiency cause congenital cataracts during infancy and presenile cataracts in the adult population. We have isolated the mouse cDNA for galactokinase, which shares extensive amino acid sequence homology, 88% identity, with a recently cloned human galactokinase. It is expressed in all tissues examined. In an interspecific backcross analysis galactokinase maps to the distal region of mouse chromosome 11, a region that is homologous to human chromosome 17q22-25. The availability of the mouse gene provides an opportunity to make a knockout model for galactokinase deficiency. SN - 1088-9051 UR - https://www.unboundmedicine.com/medline/citation/8717055/Mouse_galactokinase:_isolation_characterization_and_location_on_chromosome_11_ L2 - http://genome.cshlp.org/cgi/pmidlookup?view=long&pmid=8717055 DB - PRIME DP - Unbound Medicine ER -