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Effect of ethanol on airway caliber and nonspecific bronchial responsiveness in patients with alcohol-induced asthma.
Allergy. 1996 Jan; 51(1):52-5.A

Abstract

No study has investigated the effects of ethanol on bronchial responsiveness in patients with alcohol-induced asthma, although acetaldehyde, which is a metabolite of ethanol and is thought to be a main factor in alcohol-induced asthma, causes both bronchoconstriction and bronchial hyperresponsiveness. The purpose of this study was to investigate the direct action of ethanol on the airway in patients with alcohol-induced asthma. First, we investigated the bronchial response to inhalation of ascending doses (5, 10, and 20%) of ethanol in nine patients with alcohol-induced asthma. Then, the bronchial responsiveness to methacholine was measured in 14 patients who were pretreated with saline or 20% ethanol in a double-blind, randomized, placebo-controlled, crossover fashion. Ascending doses of inhaled ethanol caused no significant changes in FEV1. The methacholine concentrations producing a 20% fall in FEV1 (PC20-MCh) after 20% ethanol (0.769 mg/ml, GSEM 1.514) were significantly (P = 0.0357) higher than those after saline (0.493 mg/ml, GSEM 1.368). This indicates that ethanol has a reducing effect on nonspecific bronchial responsiveness in patients with alcohol-induced asthma; this paper is the first report on the effects of ethanol on bronchial responsiveness.

Authors+Show Affiliations

Division of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8721529

Citation

Myou, S, et al. "Effect of Ethanol On Airway Caliber and Nonspecific Bronchial Responsiveness in Patients With Alcohol-induced Asthma." Allergy, vol. 51, no. 1, 1996, pp. 52-5.
Myou S, Fujimura M, Nishi K, et al. Effect of ethanol on airway caliber and nonspecific bronchial responsiveness in patients with alcohol-induced asthma. Allergy. 1996;51(1):52-5.
Myou, S., Fujimura, M., Nishi, K., Watanabe, K., Matsuda, M., Ohka, T., & Matsuda, T. (1996). Effect of ethanol on airway caliber and nonspecific bronchial responsiveness in patients with alcohol-induced asthma. Allergy, 51(1), 52-5.
Myou S, et al. Effect of Ethanol On Airway Caliber and Nonspecific Bronchial Responsiveness in Patients With Alcohol-induced Asthma. Allergy. 1996;51(1):52-5. PubMed PMID: 8721529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ethanol on airway caliber and nonspecific bronchial responsiveness in patients with alcohol-induced asthma. AU - Myou,S, AU - Fujimura,M, AU - Nishi,K, AU - Watanabe,K, AU - Matsuda,M, AU - Ohka,T, AU - Matsuda,T, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 52 EP - 5 JF - Allergy JO - Allergy VL - 51 IS - 1 N2 - No study has investigated the effects of ethanol on bronchial responsiveness in patients with alcohol-induced asthma, although acetaldehyde, which is a metabolite of ethanol and is thought to be a main factor in alcohol-induced asthma, causes both bronchoconstriction and bronchial hyperresponsiveness. The purpose of this study was to investigate the direct action of ethanol on the airway in patients with alcohol-induced asthma. First, we investigated the bronchial response to inhalation of ascending doses (5, 10, and 20%) of ethanol in nine patients with alcohol-induced asthma. Then, the bronchial responsiveness to methacholine was measured in 14 patients who were pretreated with saline or 20% ethanol in a double-blind, randomized, placebo-controlled, crossover fashion. Ascending doses of inhaled ethanol caused no significant changes in FEV1. The methacholine concentrations producing a 20% fall in FEV1 (PC20-MCh) after 20% ethanol (0.769 mg/ml, GSEM 1.514) were significantly (P = 0.0357) higher than those after saline (0.493 mg/ml, GSEM 1.368). This indicates that ethanol has a reducing effect on nonspecific bronchial responsiveness in patients with alcohol-induced asthma; this paper is the first report on the effects of ethanol on bronchial responsiveness. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/8721529/Effect_of_ethanol_on_airway_caliber_and_nonspecific_bronchial_responsiveness_in_patients_with_alcohol_induced_asthma_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1996&volume=51&issue=1&spage=52 DB - PRIME DP - Unbound Medicine ER -